Sign in or Register   Sign in or Register
  |  

Mouse Anti-CLCA1 Recombinant Antibody (CBLG1-356) (CBMAB-G1338-LY)

This product is antibody recognizes CLCA1. The antibody CBLG1-356 immunoassay techniques such as: ELISA, WB.
See all CLCA1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-356
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
chloride channel regulator 1
Introduction
This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine. [provided by RefSeq, Jul 2008]
Entrez Gene ID
1179
UniProt ID
A8K7I4
Alternative Names
Chloride Channel Accessory 1; Chloride Channel; Calcium Activated; Family Member 1; Calcium-Activated Chloride Channel Family Member 1; Calcium-Activated Chloride Channel Protein 1; Chloride Channel Regulator 1; HCaCC-1; CaCC-1; HCLCA1; CACC1;
Function
May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.
Biological Process
Calcium ion transport Source: UniProtKB-KW
Cellular response to hypoxia Source: Ensembl
Chloride transport Source: InterPro
Ion transmembrane transport Source: Reactome
Cellular Location
Cell membrane; Extracellular space. Protein that remains attached to the plasma membrane appeared to be predominantly localized to microvilli.
PTM
Glycosylated.
The 125-kDa product is autoproteolytically processed by the metalloprotease domain and yields to two cell-surface-associated subunits, a 90-kDa protein and a group of 37- to 41-kDa proteins. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity.

Lee, H. J., Donati, A., Feliers, D., Sun, Y., Ding, Y., Madesh, M., ... & Kasinath, B. S. (2021). Chloride channel accessory 1 integrates chloride channel activity and mTORC1 in aging‐related kidney injury. Aging Cell, e13407.

Nyström, E. E., Arike, L., Ehrencrona, E., Hansson, G. C., & Johansson, M. E. (2019). Calcium-activated chloride channel regulator 1 (CLCA1) forms non-covalent oligomers in colonic mucus and has mucin 2–processing properties. Journal of Biological Chemistry, 294(45), 17075-17089.

Liu, C. L., & Shi, G. P. (2019). Calcium-activated chloride channel regulator 1 (CLCA1): More than a regulator of chloride transport and mucus production. World Allergy Organization Journal, 12(11), 100077.

Hu, D., Ansari, D., Bauden, M., Zhou, Q., & Andersson, R. (2019). The emerging role of calcium-activated chloride channel regulator 1 in cancer. Anticancer research, 39(4), 1661-1666.

Chen, T. J., He, H. L., Shiue, Y. L., Yang, C. C., Lin, L. C., Tian, Y. F., & Chen, S. H. (2018). High chloride channel accessory 1 expression predicts poor prognoses in patients with rectal cancer receiving chemoradiotherapy. International journal of medical sciences, 15(11), 1171.

Hu, D., Ansari, D., Zhou, Q., Sasor, A., Hilmersson, K. S., Bauden, M., ... & Andersson, R. (2018). Calcium-activated chloride channel regulator 1 as a prognostic biomarker in pancreatic ductal adenocarcinoma. BMC cancer, 18(1), 1-6.

Li, X., Hu, W., Zhou, J., Huang, Y., Peng, J., Yuan, Y., ... & Zheng, S. (2017). CLCA1 suppresses colorectal cancer aggressiveness via inhibition of the Wnt/beta-catenin signaling pathway. Cell Communication and Signaling, 15(1), 1-13.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-CLCA1 Recombinant Antibody (CBLG1-356)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare