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Rat Anti-CLEC1B Recombinant Antibody (CBXC-1525) (CBMAB-C3612-CQ)

This product is a rat antibody that recognizes CLEC1B. The antibody CBXC-1525 can be used for immunoassay techniques such as: FC.
See all CLEC1B antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBXC-1525
Antibody Isotype
IgG2b
Application
FC

Basic Information

Immunogen
RBL-2H3 cells stably expressing HA-tagged mouse CLEC2
Specificity
Mouse
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 1% BSA
Preservative
0.09% sodium azide
Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
C-type lectin domain family 1, member B
Introduction
Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011]
Entrez Gene ID
56760
UniProt ID
Q9JL99
Alternative Names
C-Type Lectin Domain Family 1 Member B; C-Type Lectin-Like Receptor 2; CLEC-2; CLEC2; C-Type Lectin Domain Family 1, Member B; 1810061I13Rik; PRO1384; QDED721; CLEC2B;
Function
C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN (PubMed:18215137).

After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2 (PubMed:18955485).

(Microbial infection) Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (SYK) and initiation of downstream tyrosine phosphorylation events and activation of PLCG2 (PubMed:16174766, PubMed:18955485).

(Microbial infection) Acts as an attachment factor for Human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets (PubMed:16940507).
Biological Process
Cell surface receptor signaling pathway Source: ProtInc
Defense response Source: ProtInc
Platelet activation Source: Reactome
Signal transduction Source: UniProtKB
Viral process Source: UniProtKB-KW
Cellular Location
Membrane
Topology
Cytoplasmic: 1-33
Helical: 34-54
Extracellular: 55-229
PTM
Glycosylated.
Phosphorylated on tyrosine residue in response to rhodocytin binding.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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