Mouse Anti-CLEC1B Recombinant Antibody (AYP1) (CBMAB-C0411-CQ)

Name: Mouse Anti-CLEC1B Recombinant Antibody (AYP1)
SKU: CBMAB-C0411-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

AYP1

Application

FC, IF, IP

Immunogen

A recombinant extracellular fragment of human CLEC-2/CLEC-1B (aa 68-229).

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
IP	1:10-1:500
IF(ICC)	1:10-1:500
FC	1:10-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

0.02% sodium azide

Concentration

1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

C-type lectin domain family 1, member B

Introduction

Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011]

Entrez Gene ID

51266

UniProt ID

Q9P126

Alternative Names

C-Type Lectin Domain Family 1 Member B; C-Type Lectin-Like Receptor 2; CLEC-2; CLEC2; C-Type Lectin Domain Family 1, Member B; 1810061I13Rik; PRO1384; QDED721; CLEC2B;

Function

C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN (PubMed:18215137).

After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2 (PubMed:18955485).

(Microbial infection) Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (SYK) and initiation of downstream tyrosine phosphorylation events and activation of PLCG2 (PubMed:16174766, PubMed:18955485).

(Microbial infection) Acts as an attachment factor for Human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets (PubMed:16940507).

Biological Process

Cell surface receptor signaling pathway Source: ProtInc
Defense response Source: ProtInc
Platelet activation Source: Reactome
Signal transduction Source: UniProtKB
Viral process Source: UniProtKB-KW

Cellular Location

Membrane

Topology

Cytoplasmic: 1-33
Helical: 34-54
Extracellular: 55-229

PTM

Glycosylated.
Phosphorylated on tyrosine residue in response to rhodocytin binding.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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