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Mouse Anti-CLEC1B Recombinant Antibody (CBFYC-1916) (CBMAB-C1981-FY)

This product is mouse antibody that recognizes CLEC1B. The antibody CBFYC-1916 can be used for immunoassay techniques such as: WB, FC.
See all CLEC1B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-1916
Antibody Isotype
IgG2
Application
WB, FC

Basic Information

Specificity
Human
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
C-type lectin domain family 1, member B
Introduction
Natural killer cells express multiple calcium-dependent lectin-like receptors, such as CD94 and NKG2D, that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells.
Entrez Gene ID
51266
UniProt ID
Q9P126
Alternative Names
C-Type Lectin Domain Family 1 Member B; C-Type Lectin-Like Receptor 2; CLEC-2; CLEC2; C-Type Lectin Domain Family 1, Member B; 1810061I13Rik; PRO1384; QDED721; CLEC2B
Function
C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN (PubMed:18215137).

After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2 (PubMed:18955485).

(Microbial infection) Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (SYK) and initiation of downstream tyrosine phosphorylation events and activation of PLCG2 (PubMed:16174766, PubMed:18955485).

(Microbial infection) Acts as an attachment factor for Human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets (PubMed:16940507).
Biological Process
Cell surface receptor signaling pathway Source: ProtInc
Defense response Source: ProtInc
Platelet activation Source: Reactome
Signal transduction Source: UniProtKB
Viral process Source: UniProtKB-KW
Cellular Location
Membrane
Topology
Cytoplasmic: 1-33
Helical: 34-54
Extracellular: 55-229
PTM
Glycosylated.
Phosphorylated on tyrosine residue in response to rhodocytin binding.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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