CLEC1B
Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells.[supplied by OMIM
Full Name
C-type lectin domain family 1, member B
Function
C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN (PubMed:18215137).
After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2 (PubMed:18955485).
(Microbial infection) Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (SYK) and initiation of downstream tyrosine phosphorylation events and activation of PLCG2 (PubMed:16174766, PubMed:18955485).
(Microbial infection) Acts as an attachment factor for Human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets (PubMed:16940507).
After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2 (PubMed:18955485).
(Microbial infection) Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (SYK) and initiation of downstream tyrosine phosphorylation events and activation of PLCG2 (PubMed:16174766, PubMed:18955485).
(Microbial infection) Acts as an attachment factor for Human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets (PubMed:16940507).
Biological Process
Cell surface receptor signaling pathway Source: ProtInc
Defense response Source: ProtInc
Platelet activation Source: Reactome
Signal transduction Source: UniProtKB
Viral process Source: UniProtKB-KW
Defense response Source: ProtInc
Platelet activation Source: Reactome
Signal transduction Source: UniProtKB
Viral process Source: UniProtKB-KW
Cellular Location
Membrane
Topology
Cytoplasmic: 1-33
Helical: 34-54
Extracellular: 55-229
Helical: 34-54
Extracellular: 55-229
PTM
Glycosylated.
Phosphorylated on tyrosine residue in response to rhodocytin binding.
Phosphorylated on tyrosine residue in response to rhodocytin binding.
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Anti-CLEC1B antibodies
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CompareTarget: CLEC1B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT2610
Application*: IH, F
Target: CLEC1B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-1917
Application*: WB
Target: CLEC1B
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 17D9
Application*: WB, F
Target: CLEC1B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: AYP1
Application*: F, IF, IP
Target: CLEC1B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-1916
Application*: WB
Target: CLEC1B
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 8J24
Application*: WB, F
Target: CLEC1B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1C10
Application*: E, IP, WB
Target: CLEC1B
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 004
Application*: E
Target: CLEC1B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: C0651
Application*: WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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