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Rat Anti-CLEC4A (AA 70-238) Recombinant Antibody (320507) (CBMAB-C0033-YY)

This product is rat antibody that recognizes CLEC4A. The antibody 320507 can be used for immunoassay techniques such as: FC, WB
See all CLEC4A antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
320507
Antibody Isotype
IgG2a
Application
FC, WB

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Protein G purified
Preservative
0.5% BSA
Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 70-238

Target

Full Name
C-Type Lectin Domain Family 4 Member A
Entrez Gene ID
26888
UniProt ID
Q9QZ15
Alternative Names
Cbl Proto-Oncogene; Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence; Cbl Proto-Oncogene, E3 Ubiquitin Protein Ligase; Casitas B-Lineage Lymphoma Proto-Oncogene; RING-Type E3 Ubiquitin Transferase CBL; Signal Transduction Protein CBL; RING Finger Protein 55; Proto-Oncogene C-Cbl; Oncogene CBL2; RNF55;
Function
C-type lectin receptor that binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca2+-dependent manner (PubMed:27015765).

Involved in regulating immune reactivity (PubMed:18258799, PubMed:10438934).

Once triggered by antigen, it is internalized by clathrin-dependent endocytosis and delivers its antigenic cargo into the antigen presentation pathway resulting in cross-priming of CD8+ T cells. This cross-presentation and cross-priming are enhanced by TLR7 and TLR8 agonists with increased expansion of the CD8+ T cells, high production of IFNG and TNF with reduced levels of IL4, IL5 and IL13 (PubMed:18258799, PubMed:20530286).

In plasmacytoid dendritic cells, inhibits TLR9-mediated IFNA and TNF production (PubMed:18258799).

May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation (PubMed:10438934).

(Microbial infection) Involved in the interaction between HIV-1 virus and dendritic cells. Enhances HIV-1 binding/entry and virus infection. Requires ITIM motif-associated signal transduction pathway involving phosphatases PTPN6 and PTPN11, SYK, Src kinases and MAP kinases.
Biological Process
Adaptive immune response Source: UniProtKB-KW
Antigen processing and presentation of exogenous peptide antigen via MHC class I Source: UniProtKB
CD8-positive, alpha-beta T cell activation Source: UniProtKB
Cell adhesion Source: ProtInc
Cell surface receptor signaling pathway Source: ProtInc
Innate immune response Source: UniProtKB-KW
Negative regulation of cytokine production Source: UniProtKB
Negative regulation of tumor necrosis factor production Source: UniProtKB
Plasmacytoid dendritic cell antigen processing and presentation Source: UniProtKB
Stimulatory C-type lectin receptor signaling pathway Source: Reactome
Viral process Source: UniProtKB-KW
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-48
Helical: 49-69
Extracellular: 70-237
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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