CLEC4A

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in inflammatory and immune response. Multiple transcript variants encoding distinct isoforms have been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

Full Name

C-Type Lectin Domain Family 4 Member A

Function

C-type lectin receptor that binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca2+-dependent manner (PubMed:27015765).

Involved in regulating immune reactivity (PubMed:18258799, PubMed:10438934).

Once triggered by antigen, it is internalized by clathrin-dependent endocytosis and delivers its antigenic cargo into the antigen presentation pathway resulting in cross-priming of CD8+ T cells. This cross-presentation and cross-priming are enhanced by TLR7 and TLR8 agonists with increased expansion of the CD8+ T cells, high production of IFNG and TNF with reduced levels of IL4, IL5 and IL13 (PubMed:18258799, PubMed:20530286).

In plasmacytoid dendritic cells, inhibits TLR9-mediated IFNA and TNF production (PubMed:18258799).

May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation (PubMed:10438934).

(Microbial infection) Involved in the interaction between HIV-1 virus and dendritic cells. Enhances HIV-1 binding/entry and virus infection. Requires ITIM motif-associated signal transduction pathway involving phosphatases PTPN6 and PTPN11, SYK, Src kinases and MAP kinases.

Biological Process

Adaptive immune response Source: UniProtKB-KW
Antigen processing and presentation of exogenous peptide antigen via MHC class I Source: UniProtKB
CD8-positive, alpha-beta T cell activation Source: UniProtKB
Cell adhesion Source: ProtInc
Cell surface receptor signaling pathway Source: ProtInc
Innate immune response Source: UniProtKB-KW
Negative regulation of cytokine production Source: UniProtKB
Negative regulation of tumor necrosis factor production Source: UniProtKB
Plasmacytoid dendritic cell antigen processing and presentation Source: UniProtKB
Stimulatory C-type lectin receptor signaling pathway Source: Reactome
Viral process Source: UniProtKB-KW

Cellular Location

Cell membrane

Topology

Cytoplasmic: 1-48
Helical: 49-69
Extracellular: 70-237

Anti-CLEC4A antibodies

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Rabbit Anti-CLEC4A Recombinant Antibody (7) (CBMAB-C8384-LY)

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Target: CLEC4A

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 7

Application*: E

CLEC4A

Anti-CLEC4A antibodies

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