Sign in or Register   Sign in or Register
  |  

Human Anti-CLEC5A Recombinant Antibody (CBFYM-0397) (CBMAB-M0501-FY)

This product is human antibody that recognizes CLEC5A. The antibody CBFYM-0397 can be used for immunoassay techniques such as: FC.
See all CLEC5A antibodies

Summary

Host Animal
Human
Specificity
Mouse
Clone
CBFYM-0397
Antibody Isotype
IgG1
Application
FC

Basic Information

Specificity
Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Preservative
0.05% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
C-Type Lectin Domain Containing 5A
Introduction
This gene encodes a member of the C-type lectin/C-type lectin-like domain superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein interacts with dnax-activation protein 12 and may play a role in cell activation. Alternative splice variants have been described but their full-length sequence has not been determined.
Entrez Gene ID
23845
UniProt ID
Q9R007
Alternative Names
C-Type Lectin Domain Containing 5A; C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 5; C-Type Lectin Domain Family 5 Member A; C-Type Lectin Superfamily Member 5; CLECSF5; MDL-1
Function
Functions as a positive regulator of osteoclastogenesis (By similarity).

Cell surface receptor that signals via TYROBP (PubMed:10449773).

Regulates inflammatory responses (By similarity).

(Microbial infection) Critical macrophage receptor for dengue virus serotypes 1-4 (PubMed:18496526, PubMed:21566123).

The binding of dengue virus to CLEC5A triggers signaling through the phosphorylation of TYROBP (PubMed:18496526).

This interaction does not result in viral entry, but stimulates proinflammatory cytokine release (PubMed:18496526).
Biological Process
Cellular defense response Source: ProtInc
Innate immune response Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Neutrophil degranulation Source: Reactome
Osteoblast development Source: UniProtKB
Signal transduction Source: ProtInc
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-4
Helical: 5-27
Extracellular: 28-188
PTM
N-glycosylated. Contains sialic acid residues.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Human Anti-CLEC5A Recombinant Antibody (CBFYM-0397)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare