Human Anti-CLEC5A Recombinant Antibody (CBFYM-0107) (CBMAB-M0120-FY)

Name: Human Anti-CLEC5A Recombinant Antibody (CBFYM-0107)
SKU: CBMAB-M0120-FY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Human

Specificity

Human

Clone

CBFYM-0107

Antibody Isotype

IgG1, κ

Application

Basic Information

Immunogen

Human CLEC5A/MDL1.

Host Species

Human

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 26-188

Target

Full Name

C-Type Lectin Domain Containing 5A

Introduction

This gene encodes a member of the C-type lectin/C-type lectin-like domain superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein interacts with dnax-activation protein 12 and may play a role in cell activation. Alternative splice variants have been described but their full-length sequence has not been determined.

Entrez Gene ID

23601

UniProt ID

Q9NY25

Alternative Names

C-Type Lectin Domain Containing 5A; C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 5; C-Type Lectin Domain Family 5 Member A; C-Type Lectin Superfamily Member 5; CLECSF5; MDL-1

Function

Functions as a positive regulator of osteoclastogenesis (By similarity).

Cell surface receptor that signals via TYROBP (PubMed:10449773).

Regulates inflammatory responses (By similarity).

(Microbial infection) Critical macrophage receptor for dengue virus serotypes 1-4 (PubMed:18496526, PubMed:21566123).

The binding of dengue virus to CLEC5A triggers signaling through the phosphorylation of TYROBP (PubMed:18496526).

This interaction does not result in viral entry, but stimulates proinflammatory cytokine release (PubMed:18496526).

Biological Process

Cellular defense response Source: ProtInc
Innate immune response Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Neutrophil degranulation Source: Reactome
Osteoblast development Source: UniProtKB
Signal transduction Source: ProtInc

Cellular Location

Cell membrane

Topology

Cytoplasmic: 1-4
Helical: 5-27
Extracellular: 28-188

PTM

N-glycosylated. Contains sialic acid residues.

More Infomation

References

Kan, H. W., Chang, C. H., Chang, Y. S., Ko, Y. T., & Hsieh, Y. L. (2021). Genetic loss-of-function of activating transcription factor 3 but not C-type lectin member 5A prevents diabetic peripheral neuropathy. Laboratory Investigation, 101(10), 1341-1352.

Chen, P. K., Hsieh, S. L., Lan, J. L., Lin, C. C., Chang, S. H., & Chen, D. Y. (2020). Elevated expression of C-type lectin domain family 5-member A (CLEC5A) and its relation to inflammatory parameters and disease course in adult-onset Still’s disease. Journal of immunology research, 2020.

Fan, H. W., Ni, Q., Fan, Y. N., Ma, Z. X., & Li, Y. B. (2019). C‐type lectin domain family 5, member A (CLEC5A, MDL‐1) promotes brain glioblastoma tumorigenesis by regulating PI3K/Akt signalling. Cell proliferation, 52(3), e12584.

Sung, P. S., & Hsieh, S. L. (2019). CLEC2 and CLEC5A: pathogenic host factors in acute viral infections. Frontiers in immunology, 10, 2867.

Teng, O., Chen, S. T., Hsu, T. L., Sia, S. F., Cole, S., Valkenburg, S. A., ... & Yen, H. L. (2017). CLEC5A-mediated enhancement of the inflammatory response in myeloid cells contributes to influenza virus pathogenicity in vivo. Journal of virology, 91(1), e01813-16.

Xiong, W., Wang, H., Lu, L., Xi, R., Wang, F., Gu, G., & Tao, R. (2017). The macrophage C-type lectin receptor CLEC5A (MDL-1) expression is associated with early plaque progression and promotes macrophage survival. Journal of translational medicine, 15(1), 1-13.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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SDS
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Second antibody and isotype control

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