Rat Anti-CLEC5A Recombinant Antibody (CBFYM-0091) (V2LY-1206-LY169)

Name: Rat Anti-CLEC5A Recombinant Antibody (CBFYM-0091)
SKU: V2LY-1206-LY169
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Rat

Specificity

Mouse

Clone

CBFYM-0091

Antibody Isotype

IgG2a

Application

FC, IHC

Basic Information

Immunogen

BaF3 mouse pro-B cell line transfected with mouse MDL-1/CLEC5A.

Host Species

Rat

Specificity

Mouse

Antibody Isotype

IgG2a

Clonality

Monoclonal Antibody

Application Notes

Application	Note
FC	2.5 µg/10^6 cells

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, Trehalose

Preservative

None

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

C-Type Lectin Domain Containing 5A

Entrez Gene ID

23845

UniProt ID

Q9R007

Function

Functions as a positive regulator of osteoclastogenesis (By similarity).

Cell surface receptor that signals via TYROBP (PubMed:10449773).

Regulates inflammatory responses (By similarity).

(Microbial infection) Critical macrophage receptor for dengue virus serotypes 1-4 (PubMed:18496526, PubMed:21566123).

The binding of dengue virus to CLEC5A triggers signaling through the phosphorylation of TYROBP (PubMed:18496526).

This interaction does not result in viral entry, but stimulates proinflammatory cytokine release (PubMed:18496526).

Biological Process

Cellular defense response Source: ProtInc
Innate immune response Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Neutrophil degranulation Source: Reactome
Osteoblast development Source: UniProtKB
Signal transduction Source: ProtInc

Cellular Location

Cell membrane

Topology

Cytoplasmic: 1-4
Helical: 5-27
Extracellular: 28-188

PTM

N-glycosylated. Contains sialic acid residues.

More Infomation

References

Kan, H. W., Chang, C. H., Chang, Y. S., Ko, Y. T., & Hsieh, Y. L. (2021). Genetic loss-of-function of activating transcription factor 3 but not C-type lectin member 5A prevents diabetic peripheral neuropathy. Laboratory Investigation, 101(10), 1341-1352.

Chen, P. K., Hsieh, S. L., Lan, J. L., Lin, C. C., Chang, S. H., & Chen, D. Y. (2020). Elevated expression of C-type lectin domain family 5-member A (CLEC5A) and its relation to inflammatory parameters and disease course in adult-onset Still’s disease. Journal of immunology research, 2020.

Fan, H. W., Ni, Q., Fan, Y. N., Ma, Z. X., & Li, Y. B. (2019). C‐type lectin domain family 5, member A (CLEC5A, MDL‐1) promotes brain glioblastoma tumorigenesis by regulating PI3K/Akt signalling. Cell proliferation, 52(3), e12584.

Sung, P. S., & Hsieh, S. L. (2019). CLEC2 and CLEC5A: pathogenic host factors in acute viral infections. Frontiers in immunology, 10, 2867.

Teng, O., Chen, S. T., Hsu, T. L., Sia, S. F., Cole, S., Valkenburg, S. A., ... & Yen, H. L. (2017). CLEC5A-mediated enhancement of the inflammatory response in myeloid cells contributes to influenza virus pathogenicity in vivo. Journal of virology, 91(1), e01813-16.

Xiong, W., Wang, H., Lu, L., Xi, R., Wang, F., Gu, G., & Tao, R. (2017). The macrophage C-type lectin receptor CLEC5A (MDL-1) expression is associated with early plaque progression and promotes macrophage survival. Journal of translational medicine, 15(1), 1-13.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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SDS
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Second antibody and isotype control

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