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Rat Anti-CLEC6A Recombinant Antibody (CBCNC-019) (CBMAB-C0912-CN)

This product is a Rat antibody that recognizes CLEC6A. The antibody CBCNC-019 can be used for immunoassay techniques such as: FC, IHC-Fr, IP.
See all CLEC6A antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBCNC-019
Antibody Isotype
IgG2a
Application
FC, IHC-Fr, IP

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4, 1% BSA
Preservative
0.09% Sodium azide
Concentration
0.1 mg/mL

Target

Full Name
C-Type Lectin Domain Containing 6A
Introduction
The protein encoded by this gene is a type II membrane receptor with an extracellular C-type lectin-like domain fold. The extracellular portion binds structures with a high mannose content and has been shown to recognize several pathogens, including C. elegans, S. cerevisiae, M. tuberculosis, C. neoformans, and house dust mite. When stimulated, the encoded protein initiates signalling through the CARD9-Bcl10-Malt1 pathway, leading to the induction of cytokines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Entrez Gene ID
56620
UniProt ID
Q9JKF4
Alternative Names
Clecsf10, Nkcl, Clec4n
Function
Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas (PubMed:23911656, PubMed:28652405).

Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (By similarity).

Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production (By similarity).

Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses (By similarity).
Biological Process
Adaptive immune response Source: UniProtKB-KW
Defense response to fungus Source: UniProtKB
Innate immune response Source: UniProtKB
Positive regulation of cytokine production Source: UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Stimulatory C-type lectin receptor signaling pathway Source: Reactome
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-20
Helical: 21-41
Extracellular: 42-209
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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