CLEC6A

The protein encoded by this gene is a type II membrane receptor with an extracellular C-type lectin-like domain fold. The extracellular portion binds structures with a high mannose content and has been shown to recognize several pathogens, including C. elegans, S. cerevisiae, M. tuberculosis, C. neoformans, and house dust mite. When stimulated, the encoded protein initiates signalling through the CARD9-Bcl10-Malt1 pathway, leading to the induction of cytokines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Full Name
C-Type Lectin Domain Containing 6A
Function
Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas (PubMed:23911656, PubMed:28652405).

Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (By similarity).

Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production (By similarity).

Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses (By similarity).
Biological Process
Adaptive immune response Source: UniProtKB-KW
Defense response to fungus Source: UniProtKB
Innate immune response Source: UniProtKB
Positive regulation of cytokine production Source: UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Stimulatory C-type lectin receptor signaling pathway Source: Reactome
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-20
Helical: 21-41
Extracellular: 42-209
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Anti-CLEC6A antibodies

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Rat Anti-CLEC6A Recombinant Antibody (CBLC162-LY) (V2LY-1206-LY184)

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Target: CLEC6A
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBLC162-LY
Application*: WB
Datasheet SDS

Rat Anti-CLEC6A Recombinant Antibody (CBCNC-019) (V2LY-1206-LY183)

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Target: CLEC6A
Host: Rat
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBCNC-019
Application*: WB, N
Functional Assay
Datasheet SDS

Rat Anti-CLEC6A Recombinant Antibody (CBCNC-018) (V2LY-1206-LY182)

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Target: CLEC6A
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBCNC-018
Application*: F
Datasheet SDS

Mouse Anti-CLEC6A Recombinant Antibody (CBWJC-2790) (V2LY-1206-LY181)

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Target: CLEC6A
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBWJC-2790
Application*: F
Datasheet SDS

Rabbit Anti-CLEC6A Recombinant Antibody (CBWJC-2789) (V2LY-1206-LY180)

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Target: CLEC6A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBWJC-2789
Application*: E
Datasheet SDS

Mouse Anti-CLEC6A Recombinant Antibody (CBXC-2172) (V2LY-1206-LY179)

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Target: CLEC6A
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBXC-2172
Application*: WB, F, P
Datasheet SDS

Mouse Anti-CLEC6A Recombinant Antibody (D0104) (V2LY-1206-LY177)

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Target: CLEC6A
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: D0104
Application*: E
Datasheet SDS

Mouse Anti-CLEC6A Recombinant Antibody (9j6) (V2LY-1206-LY175)

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Target: CLEC6A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 9j6
Application*: IH, F, IP
Datasheet SDS

Rat Anti-CLEC6A Recombinant Antibody (CBYCD-130) (V2LY-1206-LY174)

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Target: CLEC6A
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYCD-130
Application*: WB, IP
Datasheet SDS

Rabbit Anti-CLEC6A Recombinant Antibody (7B45) (CBMAB-D0107-YC)

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Target: CLEC6A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 7B45
Application*: E
Datasheet SDS

Mouse Anti-CLEC6A Recombinant Antibody (ABM2H28) (CBMAB-D0103-YC)

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Target: CLEC6A
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: ABM2H28
Application*: WB, F, IH
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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