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Mouse Anti-CLEC6A Recombinant Antibody (CBXC-2172) (V2LY-1206-LY179)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-2172
Antibody Isotype
IgG3, κ
Application
WB, FC, IHC-P

Basic Information

Immunogen
A blend of two peptides made to amino acids 44-63 and 90-106 of human Dectin-2.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG3, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB2-5 µg/ml
FC0.1 µg/10^5 cells
IHC1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
C-Type Lectin Domain Containing 6A
Entrez Gene ID
93978
UniProt ID
Q6EIG7
Function
Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas (PubMed:23911656, PubMed:28652405).

Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (By similarity).

Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production (By similarity).

Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses (By similarity).
Biological Process
Adaptive immune response Source: UniProtKB-KW
Defense response to fungus Source: UniProtKB
Innate immune response Source: UniProtKB
Positive regulation of cytokine production Source: UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Stimulatory C-type lectin receptor signaling pathway Source: Reactome
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-20
Helical: 21-41
Extracellular: 42-209
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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