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Mouse Anti-CLEC6A Recombinant Antibody (ABM2H28) (CBMAB-D0103-YC)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
ABM2H28
Antibody Isotype
IgG2a, κ
Application
WB, FC, IHC

Basic Information

Immunogen
A partial recombinant Dectin-2 protein (amino acids 70-230).
Host Species
Mouse
Specificity
Human, Mouse
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB2-4 µg/ml
FC0.5 µg/10^6 cells
IHC5 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.05% BSA
Preservative
0.05% sodium azide
Concentration
0.5 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
C-Type Lectin Domain Containing 6A
Introduction
CLEC6A is a type II membrane receptor with an extracellular C-type lectin-like domain fold. The extracellular portion binds structures with a high mannose content and has been shown to recognize several pathogens, including C. elegans, S. cerevisiae, M. tuberculosis, C. neoformans, and house dust mite. When stimulated, CLEC6A initiates signalling through the CARD9-Bcl10-Malt1 pathway, leading to the induction of cytokines.
Entrez Gene ID
Human93978
Mouse56620
UniProt ID
HumanQ6EIG7
MouseQ9JKF4
Alternative Names
C-Type Lectin Domain Containing 6A; C-Type (Calcium Dependent, Carbohydrate-Recognition Domain) Lectin, Superfamily Member 10; Dendritic Cell-Associated C-Type Lectin 2; C-Type Lectin Domain Family 6 Member A; C-Type Lectin Superfamily Member 10; DC-Associated C-Type Lectin 2; Dectin-2;
Function
Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas (PubMed:23911656, PubMed:28652405).

Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (By similarity).

Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production (By similarity).

Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses (By similarity).
Biological Process
Adaptive immune response Source: UniProtKB-KW
Defense response to fungus Source: UniProtKB
Innate immune response Source: UniProtKB
Positive regulation of cytokine production Source: UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Stimulatory C-type lectin receptor signaling pathway Source: Reactome
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-20
Helical: 21-41
Extracellular: 42-209
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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