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Mouse Anti-CMA1 Recombinant Antibody (422818) (CBMAB-C1278-LY)

This product is antibody recognizes CMA1. The antibody 422818 immunoassay techniques such as: WB, IP.
See all CMA1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
422818
Antibody Isotype
IgG2a
Application
WB, IP

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant human Chymase/CMA1, Gly20-Asn247, Accession # P23946
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Chymase 1
Introduction
This gene encodes a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Alternative splicing results in multiple variants. [provided by RefSeq, Apr 2015]
Entrez Gene ID
1215
UniProt ID
P23946
Alternative Names
Chymase 1; Chymase 1, Mast Cell; Mast Cell Protease I; Alpha-Chymase; EC 3.4.21.39; CYH; Chymase 1 Preproprotein Transcript E; Chymase 1 Preproprotein Transcript I;
Function
Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
Biological Process
Angiotensin maturation Source: Reactome
Basement membrane disassembly Source: BHF-UCL
Cellular response to glucose stimulus Source: Ensembl
Cytokine precursor processing Source: BHF-UCL
Extracellular matrix disassembly Source: BHF-UCL
Midbrain development Source: Ensembl
Positive regulation of angiogenesis Source: Ensembl
Regulation of inflammatory response Source: BHF-UCL
Cellular Location
Secreted; Cytoplasmic granule. Mast cell granules.

Ferrario, C. M., Groban, L., Wang, H., Cheng, C. P., VonCannon, J. L., Wright, K. N., ... & Ahmad, S. (2021). The Angiotensin-(1–12)/Chymase axis as an alternate component of the tissue renin angiotensin system. Molecular and Cellular Endocrinology, 529, 111119.

Shi, S., Ye, S., Mao, J., Ru, Y., Lu, Y., Wu, X., ... & Xi, Y. (2020). CMA1 is potent prognostic marker and associates with immune infiltration in gastric cancer. Autoimmunity, 53(4), 210-217.

Zhou, D., Chen, Y., Wu, J., Shen, J., Shang, Y., Zheng, L., & Xie, X. (2019). Association between chymase gene polymorphisms and atrial fibrillation in Chinese Han population. BMC Cardiovascular Disorders, 19(1), 1-5.

Sabbah, H. N., Gupta, R. C., Singh-Gupta, V., & Zhang, K. (2019). LONG-TERM THERAPY BAY 1142524, A CHYMASE-1 INHIBITOR, NORMALIZES PLASMA BIOMARKERS IN DOGS WITH CORONARY MICROEMBOLIZATION-INDUCED HEART FAILURE. Journal of the American College of Cardiology, 73(9S1), 699-699.

Varney, V. A., Nicholas, A., Warner, A., & Sumar, N. (2019). IgE-mediated systemic anaphylaxis and its association with gene polymorphisms of ACE, angiotensinogen and chymase. Journal of Asthma and Allergy, 12, 343.

Meyer, N., Woidacki, K., Knöfler, M., Meinhardt, G., Nowak, D., Velicky, P., ... & Zenclussen, A. C. (2017). Chymase-producing cells of the innate immune system are required for decidual vascular remodeling and fetal growth. Scientific reports, 7(1), 1-14.

Sabbah, H. N., Gupta, R. C., & Tinel, H. (2017). Long-term therapy with a chymase-1 inhibitor (BAY 1142524) improves left ventricular systolic function and prevents progressive chamber remodeling in dogs with heart failure. Circulation, 136(suppl_1), A11585-A11585.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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