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Rabbit Anti-CMA1 Recombinant Antibody (CBFYM-1017) (CBMAB-M1169-FY)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBFYM-1017
Antibody Isotype
IgG
Application
IHC-P, WB

Basic Information

Immunogen
Synthetic peptide within Human Chymase/CMA1/Mast Cell Chymase aa 198-247 / 247.
Host Species
Rabbit
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500
IHC-P1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
TBS, pH7.4, 0.05% BSA, 40% Glycerol
Preservative
0.05% sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Chymase 1
Introduction
This gene encodes a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Alternative splicing results in multiple variants.
Entrez Gene ID
Human1215
Mouse17228
Rat25627
UniProt ID
HumanP23946
MouseP21844
RatP50339
Alternative Names
Chymase 1; Chymase 1, Mast Cell; Mast Cell Protease I; Alpha-Chymase; EC 3.4.21.39; CYH; Chymase 1 Preproprotein Transcript E; Chymase 1 Preproprotein Transcript I
Function
Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
Biological Process
Angiotensin maturation Source: Reactome
Basement membrane disassembly Source: BHF-UCL
Cellular response to glucose stimulus Source: Ensembl
Cytokine precursor processing Source: BHF-UCL
Extracellular matrix disassembly Source: BHF-UCL
Midbrain development Source: Ensembl
Positive regulation of angiogenesis Source: Ensembl
Regulation of inflammatory response Source: BHF-UCL
Cellular Location
Secreted; Cytoplasmic granule. Mast cell granules.
More Infomation

Ferrario, C. M., Groban, L., Wang, H., Cheng, C. P., VonCannon, J. L., Wright, K. N., ... & Ahmad, S. (2021). The Angiotensin-(1–12)/Chymase axis as an alternate component of the tissue renin angiotensin system. Molecular and Cellular Endocrinology, 529, 111119.

Shi, S., Ye, S., Mao, J., Ru, Y., Lu, Y., Wu, X., ... & Xi, Y. (2020). CMA1 is potent prognostic marker and associates with immune infiltration in gastric cancer. Autoimmunity, 53(4), 210-217.

Zhou, D., Chen, Y., Wu, J., Shen, J., Shang, Y., Zheng, L., & Xie, X. (2019). Association between chymase gene polymorphisms and atrial fibrillation in Chinese Han population. BMC Cardiovascular Disorders, 19(1), 1-5.

Sabbah, H. N., Gupta, R. C., Singh-Gupta, V., & Zhang, K. (2019). LONG-TERM THERAPY BAY 1142524, A CHYMASE-1 INHIBITOR, NORMALIZES PLASMA BIOMARKERS IN DOGS WITH CORONARY MICROEMBOLIZATION-INDUCED HEART FAILURE. Journal of the American College of Cardiology, 73(9S1), 699-699.

Varney, V. A., Nicholas, A., Warner, A., & Sumar, N. (2019). IgE-mediated systemic anaphylaxis and its association with gene polymorphisms of ACE, angiotensinogen and chymase. Journal of Asthma and Allergy, 12, 343.

Meyer, N., Woidacki, K., Knöfler, M., Meinhardt, G., Nowak, D., Velicky, P., ... & Zenclussen, A. C. (2017). Chymase-producing cells of the innate immune system are required for decidual vascular remodeling and fetal growth. Scientific reports, 7(1), 1-14.

Sabbah, H. N., Gupta, R. C., & Tinel, H. (2017). Long-term therapy with a chymase-1 inhibitor (BAY 1142524) improves left ventricular systolic function and prevents progressive chamber remodeling in dogs with heart failure. Circulation, 136(suppl_1), A11585-A11585.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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