CMA1

This gene encodes a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Alternative splicing results in multiple variants. [provided by RefSeq, Apr 2015]

Chymase 1

Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.

Angiotensin maturation Source: Reactome
Basement membrane disassembly Source: BHF-UCL
Cellular response to glucose stimulus Source: Ensembl
Cytokine precursor processing Source: BHF-UCL
Extracellular matrix disassembly Source: BHF-UCL
Midbrain development Source: Ensembl
Positive regulation of angiogenesis Source: Ensembl
Regulation of inflammatory response Source: BHF-UCL

Secreted; Cytoplasmic granule. Mast cell granules.