CMA1

This gene encodes a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Alternative splicing results in multiple variants. [provided by RefSeq, Apr 2015]
Full Name
Chymase 1
Function
Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
Biological Process
Angiotensin maturation Source: Reactome
Basement membrane disassembly Source: BHF-UCL
Cellular response to glucose stimulus Source: Ensembl
Cytokine precursor processing Source: BHF-UCL
Extracellular matrix disassembly Source: BHF-UCL
Midbrain development Source: Ensembl
Positive regulation of angiogenesis Source: Ensembl
Regulation of inflammatory response Source: BHF-UCL
Cellular Location
Secreted; Cytoplasmic granule. Mast cell granules.
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Anti-CMA1 antibodies

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Mouse Anti-CMA1 Recombinant Antibody (C4685) (V2LY-1206-LY345)

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Target: CMA1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Pig, Dog
Clone: C4685
Application*: WB, P, IF, IP
Datasheet SDS

Rabbit Anti-CMA1 Recombinant Antibody (CBFYM-1019) (V2LY-1206-LY343)

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Target: CMA1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-1019
Application*: P, WB
Datasheet SDS

Mouse Anti-CMA1 Recombinant Antibody (CBFYM-1016) (V2LY-1206-LY341)

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Target: CMA1
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBFYM-1016
Application*: E
Datasheet SDS

Mouse Anti-CMA1 Recombinant Antibody (CBFYM-1014) (V2LY-1206-LY339)

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Target: CMA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Pig, Dog
Clone: CBFYM-1014
Application*: WB, P, IF
Datasheet SDS

Mouse Anti-CMA1 Recombinant Antibody (C1278) (V2LY-1206-LY338)

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Target: CMA1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Rat
Clone: C1278
Application*: WB, IP, E
Datasheet SDS

Mouse Anti-CMA1 Recombinant Antibody (CBYY-C0217) (CBMAB-C0624-YY)

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Target: CMA1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYY-C0217
Application*: P, WB
Datasheet SDS

Rabbit Anti-CMA1 Recombinant Antibody (CBFYM-1017) (CBMAB-M1169-FY)

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Target: CMA1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBFYM-1017
Application*: P, WB
Datasheet SDS

Rabbit Anti-CMA1 Recombinant Antibody (CBFYM-1015) (CBMAB-M1167-FY)

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Target: CMA1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-1015
Application*: WB, IH
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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