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Mouse Anti-CMA1 Recombinant Antibody (C1278) (V2LY-1206-LY338)


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Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
C1278
Antibody Isotype
IgG2a
Application
WB, IP, ELISA

Basic Information

Immunogen
Recombinant human Chymase/CMA1, Gly20-Asn247.
Host Species
Mouse
Specificity
Human, Rat
Antibody Isotype
IgG2a
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1 μg/ml
IP25 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Chymase 1
Entrez Gene ID
Human1215Rat
UniProt ID
HumanP23946
RatP50339
Function
Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
Biological Process
Angiotensin maturation Source: Reactome
Basement membrane disassembly Source: BHF-UCL
Cellular response to glucose stimulus Source: Ensembl
Cytokine precursor processing Source: BHF-UCL
Extracellular matrix disassembly Source: BHF-UCL
Midbrain development Source: Ensembl
Positive regulation of angiogenesis Source: Ensembl
Regulation of inflammatory response Source: BHF-UCL
Cellular Location
Secreted; Cytoplasmic granule. Mast cell granules.
More Infomation

Ferrario, C. M., Groban, L., Wang, H., Cheng, C. P., VonCannon, J. L., Wright, K. N., ... & Ahmad, S. (2021). The Angiotensin-(1–12)/Chymase axis as an alternate component of the tissue renin angiotensin system. Molecular and Cellular Endocrinology, 529, 111119.

Shi, S., Ye, S., Mao, J., Ru, Y., Lu, Y., Wu, X., ... & Xi, Y. (2020). CMA1 is potent prognostic marker and associates with immune infiltration in gastric cancer. Autoimmunity, 53(4), 210-217.

Zhou, D., Chen, Y., Wu, J., Shen, J., Shang, Y., Zheng, L., & Xie, X. (2019). Association between chymase gene polymorphisms and atrial fibrillation in Chinese Han population. BMC Cardiovascular Disorders, 19(1), 1-5.

Sabbah, H. N., Gupta, R. C., Singh-Gupta, V., & Zhang, K. (2019). LONG-TERM THERAPY BAY 1142524, A CHYMASE-1 INHIBITOR, NORMALIZES PLASMA BIOMARKERS IN DOGS WITH CORONARY MICROEMBOLIZATION-INDUCED HEART FAILURE. Journal of the American College of Cardiology, 73(9S1), 699-699.

Varney, V. A., Nicholas, A., Warner, A., & Sumar, N. (2019). IgE-mediated systemic anaphylaxis and its association with gene polymorphisms of ACE, angiotensinogen and chymase. Journal of Asthma and Allergy, 12, 343.

Meyer, N., Woidacki, K., Knöfler, M., Meinhardt, G., Nowak, D., Velicky, P., ... & Zenclussen, A. C. (2017). Chymase-producing cells of the innate immune system are required for decidual vascular remodeling and fetal growth. Scientific reports, 7(1), 1-14.

Sabbah, H. N., Gupta, R. C., & Tinel, H. (2017). Long-term therapy with a chymase-1 inhibitor (BAY 1142524) improves left ventricular systolic function and prevents progressive chamber remodeling in dogs with heart failure. Circulation, 136(suppl_1), A11585-A11585.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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