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Mouse Anti-CMKLR1 Recombinant Antibody (CBXC-1339) (CBMAB-C1607-CQ)

This product is a mouse antibody that recognizes CMKLR1. The antibody CBXC-1339 can be used for immunoassay techniques such as: FC.
See all CMKLR1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-1339
Antibody Isotype
IgG3
Application
FC

Basic Information

Immunogen
NS0 mouse myeloma cell line transfected with human ChemR23, Met1-Leu371, Accession # NP_004063
Specificity
Human
Antibody Isotype
IgG3
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
A saline solution containing BSA
Preservative
Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Chemerin Chemokine-Like Receptor 1
Introduction
CMKLR1 (Chemerin Chemokine-Like Receptor 1) is a Protein Coding gene. Diseases associated with CMKLR1 include Gerstmann Syndrome and Cataract 18. Among its related pathways are Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and chemokine receptor activity. An important paralog of this gene is GPR1.
Entrez Gene ID
1240
UniProt ID
Q99788
Alternative Names
Chemerin Chemokine-Like Receptor 1; G-Protein Coupled Receptor ChemR23; G-Protein Coupled Receptor DEZ; Chemokine-Like Receptor 1; Resolvin E1 Receptor; Chemerin Receptor; ChemR23;
Function
Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).
Biological Process
Chemotaxis Source: UniProtKB
Complement receptor mediated signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: UniProtKB
Immune response Source: ProtInc
Inflammatory response Source: GO_Central
Negative regulation of interleukin-12 production Source: UniProtKB
Negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Positive regulation of fat cell differentiation Source: UniProtKB
Positive regulation of macrophage chemotaxis Source: DFLAT
Regulation of calcium-mediated signaling Source: UniProtKB
Skeletal system development Source: ProtInc
Cellular Location
Cell membrane
Topology
Extracellular: 1-41
Helical: 42-64
Cytoplasmic: 65-75
Helical: 76-97
Extracellular: 98-114
Helical: 115-135
Cytoplasmic: 136-154
Helical: 155-176
Extracellular: 177-224
Helical: 225-245
Cytoplasmic: 246-261
Helical: 262-282
Extracellular: 283-300
Helical: 301-320
Cytoplasmic: 321-373

Fischer, T. F., Schoeder, C. T., Zellmann, T., Stichel, J., Meiler, J., & Beck-Sickinger, A. G. (2021). Cyclic analogues of the chemerin C-terminus mimic a loop conformation essential for activating the chemokine-like receptor 1. Journal of Medicinal Chemistry, 64(6), 3048-3058.

Fischer, T. F., Czerniak, A. S., Weiß, T., Zellmann, T., Zielke, L., Els-Heindl, S., & Beck-Sickinger, A. G. (2021). Cyclic derivatives of the chemerin C-terminus as metabolically stable agonists at the chemokine-like receptor 1 for cancer treatment. Cancers, 13(15), 3788.

Omori, A., Goshima, M., Kakuda, C., Kodama, T., Otani, K., Okada, M., & Yamawaki, H. (2020). Chemerin-9-induced contraction was enhanced through the upregulation of smooth muscle chemokine-like receptor 1 in isolated pulmonary artery of pulmonary arterial hypertensive rats. Pflügers Archiv-European Journal of Physiology, 472(3), 335-342.

Kumar, J. D., Aolymat, I., Tiszlavicz, L., Reisz, Z., Garalla, H. M., Beynon, R., ... & Varro, A. (2019). Chemerin acts via CMKLR1 and GPR1 to stimulate migration and invasion of gastric cancer cells: putative role of decreased TIMP-1 and TIMP-2. Oncotarget, 10(2), 98.

Yao, J., Li, Z., Fu, Y., Wu, R., Wang, Y., Liu, C., ... & Zhang, H. (2019). Involvement of obesity-associated upregulation of chemerin/chemokine-like receptor 1 in oxidative stress and apoptosis in ovaries and granulosa cells. Biochemical and biophysical research communications, 510(3), 449-455.

Zhao, H., Yan, D., Xiang, L., Huang, C., Li, J., Yu, X., ... & Zhang, J. V. (2019). Chemokine-like receptor 1 deficiency leads to lower bone mass in male mice. Cellular and Molecular Life Sciences, 76(2), 355-367.

Dranse, H. J., Zheng, A., Comeau, A. M., Langille, M. G., Zabel, B. A., & Sinal, C. J. (2018). The impact of chemerin or chemokine-like receptor 1 loss on the mouse gut microbiome. PeerJ, 6, e5494.

Yang, X., Yao, J., Wei, Q., Ye, J., Yin, X., Quan, X., ... & Xing, H. (2018). Role of chemerin/CMKLR1 in the maintenance of early pregnancy. Frontiers of medicine, 12(5), 525-532.

Perumalsamy, S., Ain Aqilah Mohd Zin, N., Teguh Widodo, R., Azman Wan Ahmad, W., Vethakkan, R. D., & Zaman Huri, H. (2017). Chemokine like receptor-1 (CMKLR-1) receptor: a potential therapeutic target in management of chemerin induced type 2 diabetes mellitus and cancer. Current pharmaceutical design, 23(25), 3689-3698.

Muruganandan, S., Govindarajan, R., McMullen, N. M., & Sinal, C. J. (2017). Chemokine-like receptor 1 is a novel Wnt target gene that regulates mesenchymal stem cell differentiation. Stem cells, 35(3), 711-724.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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