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Mouse Anti-CNR2 Recombinant Antibody (CBYY-C3114) (CBMAB-C4557-YY)

This product is mouse antibody that recognizes CNR2. The antibody CBYY-C3114 can be used for immunoassay techniques such as: FC
See all CNR2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-C3114
Antibody Isotype
IgG2b
Application
FC

Basic Information

Immunogen
Human embryonic kidney cell line HEK293-derived transfected with human Cannabinoid R2/CB2/CNR2, Met1-Cys360, Accession # NP_001832
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Protein A/G purified
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cannabinoid Receptor 2
Entrez Gene ID
1269
UniProt ID
P34972
Alternative Names
Chromodomain Helicase DNA Binding Protein 4; Mi-2 Autoantigen 218 KDa Protein; ATP-Dependent Helicase CHD4; Mi2-BETA; CHD-4; Chromodomain-Helicase-DNA-Binding Protein 4;
Function
Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: GO_Central
Cannabinoid signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: Reactome
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
Immune response Source: ProtInc
Inflammatory response Source: UniProtKB-KW
Leukocyte chemotaxis Source: Ensembl
Negative regulation of action potential Source: Ensembl
Negative regulation of inflammatory response Source: Ensembl
Negative regulation of mast cell activation Source: Ensembl
Negative regulation of nitric-oxide synthase activity Source: Ensembl
Negative regulation of synaptic transmission, GABAergic Source: Ensembl
Regulation of metabolic process Source: GO_Central
Response to amphetamine Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Sensory perception of pain Source: Ensembl
Cellular Location
Cell membrane; Dendrite; Perikaryon. Localizes to apical dendrite of pyramidal neurons.
Topology
Extracellular: 1-33
Helical: 34-59
Cytoplasmic: 60-71
Helical: 72-92
Extracellular: 93-104
Helical: 105-129
Cytoplasmic: 130-149
Helical: 150-172
Extracellular: 173-188
Helical: 189-214
Cytoplasmic: 215-246
Helical: 247-267
Extracellular: 268-279
Helical: 280-301
Cytoplasmic: 302-360
PTM
Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor.

Wei, C., Huang, L., Zheng, Y., & Cai, X. (2021). Selective activation of cannabinoid receptor 2 regulates Treg/Th17 balance to ameliorate neutrophilic asthma in mice. Annals of Translational Medicine, 9(12).

Peiró, A. M., García-Gutiérrez, M. S., Planelles, B., Femenía, T., Mingote, C., Jiménez-Treviño, L., ... & Manzanares, J. (2020). Association of cannabinoid receptor genes (CNR1 and CNR2) polymorphisms and panic disorder. Anxiety, Stress, & Coping, 33(3), 256-265.

Xu, A., Yang, Y., Shao, Y., Wu, M., & Sun, Y. (2020). Activation of cannabinoid receptor type 2-induced osteogenic differentiation involves autophagy induction and p62-mediated Nrf2 deactivation. Cell Communication and Signaling, 18(1), 1-11.

Ismail, M., & Khawaja, G. (2018). Study of cannabinoid receptor 2 Q63R gene polymorphism in Lebanese patients with rheumatoid arthritis. Clinical rheumatology, 37(11), 2933-2938.

Wang, B., Lian, K., Li, J., & Mei, G. (2018). Restoration of osteogenic differentiation by overexpression of cannabinoid receptor 2 in bone marrow mesenchymal stem cells isolated from osteoporotic patients. Experimental and therapeutic medicine, 15(1), 357-364.

Rowley, S., Sun, X., Lima, I. V., Tavenier, A., de Oliveira, A. C. P., Dey, S. K., & Danzer, S. C. (2017). Cannabinoid receptor 1/2 double‐knockout mice develop epilepsy. Epilepsia, 58(12), e162-e166.

Elbaz, M., Ahirwar, D., Ravi, J., Nasser, M. W., & Ganju, R. K. (2017). Novel role of cannabinoid receptor 2 in inhibiting EGF/EGFR and IGF-I/IGF-IR pathways in breast cancer. Oncotarget, 8(18), 29668.

de Luis, D. A., Izaola, O., Primo, D., de la Fuente, B., & Aller, R. (2017). Polymorphism rs3123554 in the cannabinoid receptor gene type 2 (CNR2) reveals effects on body weight and insulin resistance in obese subjects. Endocrinología, Diabetes y Nutrición (English ed.), 64(8), 440-445.

Marino, S., & Idris, A. I. (2017). Emerging therapeutic targets in cancer induced bone disease: a focus on the peripheral type 2 cannabinoid receptor. Pharmacological Research, 119, 391-403.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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