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Mouse Anti-CNR2 Recombinant Antibody (3C7) (CBMAB-C5825-LY)

This product is antibody recognizes CNR2. The antibody 3C7 immunoassay techniques such as: WB, IP, IF, ELISA.
See all CNR2 antibodies
Published Data
Fig.1 Localization of the Individual Cnr Genes to Distinct Subpopulations of Neurons within the Olfactory Bulb.
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FIg.2 Western blot analyses of CB2.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
3C7
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cannabinoid Receptor 2
Introduction
CNR2 (Cannabinoid Receptor 2) is a Protein Coding gene. Diseases associated with CNR2 include Cannabis Abuse and Glycerol Kinase Deficiency. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and cannabinoid receptor activity.
An important paralog of this gene is CNR1.
Entrez Gene ID
1269
UniProt ID
P34972
Alternative Names
Cannabinoid Receptor 2; Cannabinoid Receptor 2 (Macrophage); CB-2; CB2; CX5; Testis-Dominant CNR2 Isoform CB2; CB2A; CB2B; HCB2;
Function
Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: GO_Central
Cannabinoid signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: Reactome
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
Immune response Source: ProtInc
Inflammatory response Source: UniProtKB-KW
Leukocyte chemotaxis Source: Ensembl
Negative regulation of action potential Source: Ensembl
Negative regulation of inflammatory response Source: Ensembl
Negative regulation of mast cell activation Source: Ensembl
Negative regulation of nitric-oxide synthase activity Source: Ensembl
Negative regulation of synaptic transmission, GABAergic Source: Ensembl
Regulation of metabolic process Source: GO_Central
Response to amphetamine Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Sensory perception of pain Source: Ensembl
Cellular Location
Cell membrane; Dendrite; Perikaryon. Localizes to apical dendrite of pyramidal neurons.
Topology
Extracellular: 1-33
Helical: 34-59
Cytoplasmic: 60-71
Helical: 72-92
Extracellular: 93-104
Helical: 105-129
Cytoplasmic: 130-149
Helical: 150-172
Extracellular: 173-188
Helical: 189-214
Cytoplasmic: 215-246
Helical: 247-267
Extracellular: 268-279
Helical: 280-301
Cytoplasmic: 302-360
PTM
Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor.

Wei, C., Huang, L., Zheng, Y., & Cai, X. (2021). Selective activation of cannabinoid receptor 2 regulates Treg/Th17 balance to ameliorate neutrophilic asthma in mice. Annals of Translational Medicine, 9(12).

Peiró, A. M., García-Gutiérrez, M. S., Planelles, B., Femenía, T., Mingote, C., Jiménez-Treviño, L., ... & Manzanares, J. (2020). Association of cannabinoid receptor genes (CNR1 and CNR2) polymorphisms and panic disorder. Anxiety, Stress, & Coping, 33(3), 256-265.

Xu, A., Yang, Y., Shao, Y., Wu, M., & Sun, Y. (2020). Activation of cannabinoid receptor type 2-induced osteogenic differentiation involves autophagy induction and p62-mediated Nrf2 deactivation. Cell Communication and Signaling, 18(1), 1-11.

Ismail, M., & Khawaja, G. (2018). Study of cannabinoid receptor 2 Q63R gene polymorphism in Lebanese patients with rheumatoid arthritis. Clinical rheumatology, 37(11), 2933-2938.

Wang, B., Lian, K., Li, J., & Mei, G. (2018). Restoration of osteogenic differentiation by overexpression of cannabinoid receptor 2 in bone marrow mesenchymal stem cells isolated from osteoporotic patients. Experimental and therapeutic medicine, 15(1), 357-364.

Rowley, S., Sun, X., Lima, I. V., Tavenier, A., de Oliveira, A. C. P., Dey, S. K., & Danzer, S. C. (2017). Cannabinoid receptor 1/2 double‐knockout mice develop epilepsy. Epilepsia, 58(12), e162-e166.

Elbaz, M., Ahirwar, D., Ravi, J., Nasser, M. W., & Ganju, R. K. (2017). Novel role of cannabinoid receptor 2 in inhibiting EGF/EGFR and IGF-I/IGF-IR pathways in breast cancer. Oncotarget, 8(18), 29668.

de Luis, D. A., Izaola, O., Primo, D., de la Fuente, B., & Aller, R. (2017). Polymorphism rs3123554 in the cannabinoid receptor gene type 2 (CNR2) reveals effects on body weight and insulin resistance in obese subjects. Endocrinología, Diabetes y Nutrición (English ed.), 64(8), 440-445.

Marino, S., & Idris, A. I. (2017). Emerging therapeutic targets in cancer induced bone disease: a focus on the peripheral type 2 cannabinoid receptor. Pharmacological Research, 119, 391-403.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

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