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CNR2

CNR2 (Cannabinoid Receptor 2) is a Protein Coding gene. Diseases associated with CNR2 include Cannabis Abuse and Glycerol Kinase Deficiency. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and cannabinoid receptor activity. An important paralog of this gene is CNR1.
Full Name
Cannabinoid Receptor 2
Function
Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: GO_Central
Cannabinoid signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: Reactome
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
Immune response Source: ProtInc
Inflammatory response Source: UniProtKB-KW
Leukocyte chemotaxis Source: Ensembl
Negative regulation of action potential Source: Ensembl
Negative regulation of inflammatory response Source: Ensembl
Negative regulation of mast cell activation Source: Ensembl
Negative regulation of nitric-oxide synthase activity Source: Ensembl
Negative regulation of synaptic transmission, GABAergic Source: Ensembl
Regulation of metabolic process Source: GO_Central
Response to amphetamine Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Sensory perception of pain Source: Ensembl
Cellular Location
Cell membrane; Dendrite; Perikaryon. Localizes to apical dendrite of pyramidal neurons.
Topology
Extracellular: 1-33
Helical: 34-59
Cytoplasmic: 60-71
Helical: 72-92
Extracellular: 93-104
Helical: 105-129
Cytoplasmic: 130-149
Helical: 150-172
Extracellular: 173-188
Helical: 189-214
Cytoplasmic: 215-246
Helical: 247-267
Extracellular: 268-279
Helical: 280-301
Cytoplasmic: 302-360
PTM
Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor.

Anti-CNR2 antibodies

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Target: CNR2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 3C7
Application*: WB, IP, IF, E
Target: CNR2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG753
Application*: WB: 1:500~1:1000 ELISA: 1:5000
Target: CNR2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-C3114
Application*: F
Target: CNR2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBLNC-138
Application*: F
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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