CNR2

CNR2 (Cannabinoid Receptor 2) is a Protein Coding gene. Diseases associated with CNR2 include Cannabis Abuse and Glycerol Kinase Deficiency. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and cannabinoid receptor activity. An important paralog of this gene is CNR1.

Full Name

Cannabinoid Receptor 2

Function

Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: GO_Central
Cannabinoid signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: Reactome
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
Immune response Source: ProtInc
Inflammatory response Source: UniProtKB-KW
Leukocyte chemotaxis Source: Ensembl
Negative regulation of action potential Source: Ensembl
Negative regulation of inflammatory response Source: Ensembl
Negative regulation of mast cell activation Source: Ensembl
Negative regulation of nitric-oxide synthase activity Source: Ensembl
Negative regulation of synaptic transmission, GABAergic Source: Ensembl
Regulation of metabolic process Source: GO_Central
Response to amphetamine Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Sensory perception of pain Source: Ensembl

Cellular Location

Cell membrane; Dendrite; Perikaryon. Localizes to apical dendrite of pyramidal neurons.

Topology

Extracellular: 1-33
Helical: 34-59
Cytoplasmic: 60-71
Helical: 72-92
Extracellular: 93-104
Helical: 105-129
Cytoplasmic: 130-149
Helical: 150-172
Extracellular: 173-188
Helical: 189-214
Cytoplasmic: 215-246
Helical: 247-267
Extracellular: 268-279
Helical: 280-301
Cytoplasmic: 302-360

PTM

Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor.