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Rabbit Anti-CNR2 Recombinant Antibody (EG753) (V2LY-1206-LY508)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
EG753
Antibody Isotype
IgG
Application
IF, IHC, WB

Basic Information

Immunogen
Peptides corresponding to human CNR2.
Host Species
Rabbit
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500
IF(ICC)1:500
IHC1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
0.09% sodium azide
Concentration
0.5 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cannabinoid Receptor 2
Entrez Gene ID
Human1269
Mouse12802
UniProt ID
HumanP34972
MouseP47936
Function
Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: GO_Central
Cannabinoid signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: Reactome
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
Immune response Source: ProtInc
Inflammatory response Source: UniProtKB-KW
Leukocyte chemotaxis Source: Ensembl
Negative regulation of action potential Source: Ensembl
Negative regulation of inflammatory response Source: Ensembl
Negative regulation of mast cell activation Source: Ensembl
Negative regulation of nitric-oxide synthase activity Source: Ensembl
Negative regulation of synaptic transmission, GABAergic Source: Ensembl
Regulation of metabolic process Source: GO_Central
Response to amphetamine Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Sensory perception of pain Source: Ensembl
Cellular Location
Cell membrane; Dendrite; Perikaryon. Localizes to apical dendrite of pyramidal neurons.
Topology
Extracellular: 1-33
Helical: 34-59
Cytoplasmic: 60-71
Helical: 72-92
Extracellular: 93-104
Helical: 105-129
Cytoplasmic: 130-149
Helical: 150-172
Extracellular: 173-188
Helical: 189-214
Cytoplasmic: 215-246
Helical: 247-267
Extracellular: 268-279
Helical: 280-301
Cytoplasmic: 302-360
PTM
Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor.
More Infomation

Wei, C., Huang, L., Zheng, Y., & Cai, X. (2021). Selective activation of cannabinoid receptor 2 regulates Treg/Th17 balance to ameliorate neutrophilic asthma in mice. Annals of Translational Medicine, 9(12).

Peiró, A. M., García-Gutiérrez, M. S., Planelles, B., Femenía, T., Mingote, C., Jiménez-Treviño, L., ... & Manzanares, J. (2020). Association of cannabinoid receptor genes (CNR1 and CNR2) polymorphisms and panic disorder. Anxiety, Stress, & Coping, 33(3), 256-265.

Xu, A., Yang, Y., Shao, Y., Wu, M., & Sun, Y. (2020). Activation of cannabinoid receptor type 2-induced osteogenic differentiation involves autophagy induction and p62-mediated Nrf2 deactivation. Cell Communication and Signaling, 18(1), 1-11.

Ismail, M., & Khawaja, G. (2018). Study of cannabinoid receptor 2 Q63R gene polymorphism in Lebanese patients with rheumatoid arthritis. Clinical rheumatology, 37(11), 2933-2938.

Wang, B., Lian, K., Li, J., & Mei, G. (2018). Restoration of osteogenic differentiation by overexpression of cannabinoid receptor 2 in bone marrow mesenchymal stem cells isolated from osteoporotic patients. Experimental and therapeutic medicine, 15(1), 357-364.

Rowley, S., Sun, X., Lima, I. V., Tavenier, A., de Oliveira, A. C. P., Dey, S. K., & Danzer, S. C. (2017). Cannabinoid receptor 1/2 double‐knockout mice develop epilepsy. Epilepsia, 58(12), e162-e166.

Elbaz, M., Ahirwar, D., Ravi, J., Nasser, M. W., & Ganju, R. K. (2017). Novel role of cannabinoid receptor 2 in inhibiting EGF/EGFR and IGF-I/IGF-IR pathways in breast cancer. Oncotarget, 8(18), 29668.

de Luis, D. A., Izaola, O., Primo, D., de la Fuente, B., & Aller, R. (2017). Polymorphism rs3123554 in the cannabinoid receptor gene type 2 (CNR2) reveals effects on body weight and insulin resistance in obese subjects. Endocrinología, Diabetes y Nutrición (English ed.), 64(8), 440-445.

Marino, S., & Idris, A. I. (2017). Emerging therapeutic targets in cancer induced bone disease: a focus on the peripheral type 2 cannabinoid receptor. Pharmacological Research, 119, 391-403.

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For research use only. Not intended for any clinical use.

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