Mouse Anti-CNR2 Recombinant Antibody (CBYY-C3114) (V2LY-1206-LY507)

Name: Mouse Anti-CNR2 Recombinant Antibody (CBYY-C3114)
SKU: V2LY-1206-LY507
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYY-C3114

Application

WB, IF, IHC-P, FC

Immunogen

Human Cannabinoid R2/CB2/CNR2 Met1-Cys360.

Host Species

Mouse

Specificity

Human, Mouse, E. coli

Antibody Isotype

IgG2b

Clonality

Monoclonal Antibody

Application Notes

Application	Note
FC	0.25 µg/10^6 cells

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, Trehalose

Preservative

None

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Cannabinoid Receptor 2

Entrez Gene ID

Human	1269
Mouse	12802

UniProt ID

Human	P34972
Mouse	P47936

Function

Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: GO_Central
Cannabinoid signaling pathway Source: GO_Central
G protein-coupled receptor signaling pathway Source: Reactome
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
Immune response Source: ProtInc
Inflammatory response Source: UniProtKB-KW
Leukocyte chemotaxis Source: Ensembl
Negative regulation of action potential Source: Ensembl
Negative regulation of inflammatory response Source: Ensembl
Negative regulation of mast cell activation Source: Ensembl
Negative regulation of nitric-oxide synthase activity Source: Ensembl
Negative regulation of synaptic transmission, GABAergic Source: Ensembl
Regulation of metabolic process Source: GO_Central
Response to amphetamine Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Sensory perception of pain Source: Ensembl

Cellular Location

Cell membrane; Dendrite; Perikaryon. Localizes to apical dendrite of pyramidal neurons.

Topology

Extracellular: 1-33
Helical: 34-59
Cytoplasmic: 60-71
Helical: 72-92
Extracellular: 93-104
Helical: 105-129
Cytoplasmic: 130-149
Helical: 150-172
Extracellular: 173-188
Helical: 189-214
Cytoplasmic: 215-246
Helical: 247-267
Extracellular: 268-279
Helical: 280-301
Cytoplasmic: 302-360

PTM

Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor.

Wei, C., Huang, L., Zheng, Y., & Cai, X. (2021). Selective activation of cannabinoid receptor 2 regulates Treg/Th17 balance to ameliorate neutrophilic asthma in mice. Annals of Translational Medicine, 9(12).

Peiró, A. M., García-Gutiérrez, M. S., Planelles, B., Femenía, T., Mingote, C., Jiménez-Treviño, L., ... & Manzanares, J. (2020). Association of cannabinoid receptor genes (CNR1 and CNR2) polymorphisms and panic disorder. Anxiety, Stress, & Coping, 33(3), 256-265.

Xu, A., Yang, Y., Shao, Y., Wu, M., & Sun, Y. (2020). Activation of cannabinoid receptor type 2-induced osteogenic differentiation involves autophagy induction and p62-mediated Nrf2 deactivation. Cell Communication and Signaling, 18(1), 1-11.

Ismail, M., & Khawaja, G. (2018). Study of cannabinoid receptor 2 Q63R gene polymorphism in Lebanese patients with rheumatoid arthritis. Clinical rheumatology, 37(11), 2933-2938.

Wang, B., Lian, K., Li, J., & Mei, G. (2018). Restoration of osteogenic differentiation by overexpression of cannabinoid receptor 2 in bone marrow mesenchymal stem cells isolated from osteoporotic patients. Experimental and therapeutic medicine, 15(1), 357-364.

Rowley, S., Sun, X., Lima, I. V., Tavenier, A., de Oliveira, A. C. P., Dey, S. K., & Danzer, S. C. (2017). Cannabinoid receptor 1/2 double‐knockout mice develop epilepsy. Epilepsia, 58(12), e162-e166.

Elbaz, M., Ahirwar, D., Ravi, J., Nasser, M. W., & Ganju, R. K. (2017). Novel role of cannabinoid receptor 2 in inhibiting EGF/EGFR and IGF-I/IGF-IR pathways in breast cancer. Oncotarget, 8(18), 29668.

de Luis, D. A., Izaola, O., Primo, D., de la Fuente, B., & Aller, R. (2017). Polymorphism rs3123554 in the cannabinoid receptor gene type 2 (CNR2) reveals effects on body weight and insulin resistance in obese subjects. Endocrinología, Diabetes y Nutrición (English ed.), 64(8), 440-445.

Marino, S., & Idris, A. I. (2017). Emerging therapeutic targets in cancer induced bone disease: a focus on the peripheral type 2 cannabinoid receptor. Pharmacological Research, 119, 391-403.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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