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Mouse Anti-COLEC12 Recombinant Antibody (CBXC-0521) (CBMAB-C5429-CQ)

This product is a mouse antibody that recognizes COLEC12. The antibody CBXC-0521 can be used for immunoassay techniques such as: ELISA, WB.
See all COLEC12 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-0521
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
collectin sub-family member 12
Introduction
COLEC12 (Collectin Subfamily Member 12) is a Protein Coding gene. Diseases associated with COLEC12 include Syndromic X-Linked Intellectual Disability Snyder Type. Among its related pathways are Phagosome and Binding and Uptake of Ligands by Scavenger Receptors. Gene Ontology (GO) annotations related to this gene include scavenger receptor activity and signaling pattern recognition receptor activity. An important paralog of this gene is SCARA3.
Entrez Gene ID
81035
UniProt ID
Q5KU26
Alternative Names
Collectin Subfamily Member 12; Scavenger Receptor With C-Type Lectin; Nurse Cell Scavenger Receptor 2; Collectin Placenta Protein 1; SCARA4; HCL-P1; CLP1; NSR2;
Function
Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid-beta in Alzheimer disease.
Biological Process
Carbohydrate mediated signaling Source: UniProtKB
Cellular response to exogenous dsRNA Source: UniProtKB
Defense response Source: UniProtKB
Defense response to bacterium Source: UniProtKB
Innate immune response Source: UniProtKB
Phagocytosis, recognition Source: UniProtKB
Positive regulation of cell adhesion molecule production Source: UniProtKB
Receptor-mediated endocytosis Source: Reactome
Regulation of immune response Source: Reactome
Toll-like receptor 3 signaling pathway Source: UniProtKB
Cellular Location
Membrane. Forms clusters on the cell surface.
Topology
Cytoplasmic: 1-37
Helical: 38-58
Extracellular: 59-742
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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