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Rat Anti-COLEC12 Recombinant Antibody (RM0400-4U28) (CBMAB-1412-CN)

This product is a rat antibody that recognizes COLEC12 of mouse. The antibody RM0400-4U28 can be used for immunoassay techniques such as: WB.
See all COLEC12 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
RM0400-4U28
Antibody Isotype
IgG2
Application
WB

Basic Information

Immunogen
Recombinant fragment corresponding to Mouse Colec12 aa. 101-742.
Specificity
Mouse
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
collectin sub-family member 12
Introduction
Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. It binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. The protein may also play a role in the clearance of amyloid beta in Alzheimer disease.
Entrez Gene ID
140792
UniProt ID
Q8K4Q8
Alternative Names
SRCL; CL-P1; Scara4
Function
Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid-beta in Alzheimer disease.
Biological Process
Carbohydrate mediated signaling Source: UniProtKB
Cellular response to exogenous dsRNA Source: UniProtKB
Defense response Source: UniProtKB
Defense response to bacterium Source: UniProtKB
Innate immune response Source: UniProtKB
Phagocytosis, recognition Source: UniProtKB
Positive regulation of cell adhesion molecule production Source: UniProtKB
Receptor-mediated endocytosis Source: Reactome
Regulation of immune response Source: Reactome
Toll-like receptor 3 signaling pathway Source: UniProtKB
Cellular Location
Membrane. Forms clusters on the cell surface.
Topology
Cytoplasmic: 1-37
Helical: 38-58
Extracellular: 59-742
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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