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Rabbit Anti-COMT Recombinant Antibody (EPR6490) (CBMAB-1413-CN)

This product is a rabbit antibody that recognizes COMT of human. The antibody EPR6490 can be used for immunoassay techniques such as: WB, IHC-P.
See all COMT antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EPR6490
Antibody Isotype
IgG
Application
WB, IHC-P

Basic Information

Immunogen
Synthetic peptide, corresponding to residues in Human COMT (Uniprot ID: P21964).
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
49% PBS, 50% Glycerol, 0.05% BSA, pH 7.2
Preservative
0.01% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Catechol-O-Methyltransferase
Introduction
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This protein catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Entrez Gene ID
Human1312
Mouse12846
Rat24267
UniProt ID
HumanP21964
MouseO88587
RatP22734
Alternative Names
HEL-S-98n
Function
Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
Biological Process
Catecholamine catabolic process Source: UniProtKB
Developmental process Source: GO_Central
Dopamine metabolic process Source: GO_Central
Methylation Source: UniProtKB
Neurotransmitter catabolic process Source: UniProtKB-KW
Cellular Location
Isoform Soluble: Cytoplasm
Isoform Membrane-bound: Cell membrane
Involvement in disease
Schizophrenia (SCZD):
A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
Topology
Cytoplasmic: 1-6
Helical: 7-26
Extracellular: 27-271
PTM
The N-terminus is blocked.

Sprague, B. N., Rosso, A. L., Zhu, X., Bohnen, N. I., & Rosano, C. (2021). Catechol‐O‐methyltransferase (COMT) polymorphism predicts rapid gait speed changes in healthy older adults. Journal of the American Geriatrics Society, 69(11), 3194-3202.

Cao, C., Cao, L., & Chen, J. (2019). Differences in sensitivity to environment depending on Catechol-O-Methyltransferase (COMT) gene? A meta-analysis of child and adolescent gene-by-environment studies. Journal of Youth and Adolescence, 48(4), 655-667.

Nogueira, N. G., Fernandes, L. A., Ferreira, B. P., Batista, M. T., Alves, K. C., & Parma, J. O. (2019). Association between the Catechol-O-Methyltransferase (COMT) Val158Met polymorphism and manual performance asymmetries. Perceptual and Motor Skills, 126(3), 349-365.

Nogueira, N. G. D. H. M., Bacelar, M. F. B., de Paula Ferreira, B., Parma, J. O., & Lage, G. M. (2019). Association between the catechol-O-methyltransferase (COMT) Val158Met polymorphism and motor behavior in healthy adults: a study review. Brain Research Bulletin, 144, 223-232.

Satterfield, B. C., Hinson, J. M., Whitney, P., Schmidt, M. A., Wisor, J. P., & Van Dongen, H. P. (2018). Catechol-O-methyltransferase (COMT) genotype affects cognitive control during total sleep deprivation. Cortex, 99, 179-186.

Patel, C. N., Georrge, J. J., Modi, K. M., Narechania, M. B., Patel, D. P., Gonzalez, F. J., & Pandya, H. A. (2018). Pharmacophore-based virtual screening of catechol-o-methyltransferase (COMT) inhibitors to combat Alzheimer’s disease. Journal of Biomolecular Structure and Dynamics, 36(15), 3938-3957.

Parkin, G. M., Udawela, M., Gibbons, A., Scarr, E., & Dean, B. (2018). Catechol-O-methyltransferase (COMT) genotypes are associated with varying soluble, but not membrane-bound COMT protein in the human prefrontal cortex. Journal of human genetics, 63(12), 1251-1258.

Lin, C. H., Chaudhuri, K., Fan, J. Y., Ko, C. I., Rizos, A., Chang, C. W., ... & Wu, Y. R. (2017). Depression and Catechol-O-methyltransferase (COMT) genetic variants are associated with pain in Parkinson’s disease. Scientific reports, 7(1), 1-10.

Bastos, P., Gomes, T., & Ribeiro, L. (2017). Catechol-O-methyltransferase (COMT): an update on its role in cancer, neurological and cardiovascular diseases. Reviews of Physiology, Biochemistry and Pharmacology, Vol. 173, 1-39.

Matsuzaka, C. T., Christofolini, D., Ota, V. K., Gadelha, A., Berberian, A. A., Noto, C., ... & Bressan, R. A. (2017). Catechol-O-methyltransferase (COMT) polymorphisms modulate working memory in individuals with schizophrenia and healthy controls. Brazilian Journal of Psychiatry, 39, 302-308.

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For research use only. Not intended for any clinical use.

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