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Rabbit Anti-COPS5 Recombinant Antibody (EG783) (CBMAB-EN938-LY)

The product is antibody recognizes COPS5. The antibody EG783 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:1000.
See all COPS5 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
EG783
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:1000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human COPS5.
Specificity
Human, Mouse
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
COP9 Signalosome Subunit 5
Introduction
COPS5 (COP9 Signalosome Subunit 5) is a Protein Coding gene. Diseases associated with COPS5 include Xeroderma Pigmentosum, Complementation Group E. Among its related pathways are MIF Action Through Endocytic Pathway and Transcription-Coupled Nucleotide Excision Repair (TC-NER). Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and thiol-dependent ubiquitin-specific protease activity.
Entrez Gene ID
Human10987
Mouse26754
UniProt ID
HumanQ92905
MouseO35864
Alternative Names
COP9 Signalosome Subunit 5; Jun Activation Domain-Binding Protein 1; Signalosome Subunit 5; CSN5; JAB1; SGN5; COP9 (Constitutive Photomorphogenic, Arabidopsis, Homolog) Subunit 5; COP9 Constitutive Photomorphogenic Homolog Subunit 5 (Arabidopsis);
Function
Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2.
Biological Process
Exosomal secretion Source: FlyBase
Negative regulation of apoptotic process Source: UniProtKB
Nucleotide-excision repair, DNA damage recognition Source: Reactome
Positive regulation of DNA-binding transcription factor activity Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Post-translational protein modification Source: Reactome
Protein deneddylation Source: UniProtKB
Protein deubiquitination Source: FlyBase
Regulation of cell cycle Source: Ensembl
Regulation of IRE1-mediated unfolded protein response Source: ParkinsonsUK-UCL
Regulation of JNK cascade Source: UniProtKB
Transcription-coupled nucleotide-excision repair Source: Reactome
Translation Source: ProtInc
Cellular Location
Cytosol; Nucleus; Perinuclear region; Synaptic vesicle. Nuclear localization is diminished in the presence of IFIT3.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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