loading...

COPS5

COPS5 (COP9 Signalosome Subunit 5) is a Protein Coding gene. Diseases associated with COPS5 include Xeroderma Pigmentosum, Complementation Group E. Among its related pathways are MIF Action Through Endocytic Pathway and Transcription-Coupled Nucleotide Excision Repair (TC-NER). Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and thiol-dependent ubiquitin-specific protease activity.

Full Name

COP9 Signalosome Subunit 5

Function

Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2.

Biological Process

Exosomal secretion Source: FlyBase
Negative regulation of apoptotic process Source: UniProtKB
Nucleotide-excision repair, DNA damage recognition Source: Reactome
Positive regulation of DNA-binding transcription factor activity Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Post-translational protein modification Source: Reactome
Protein deneddylation Source: UniProtKB
Protein deubiquitination Source: FlyBase
Regulation of cell cycle Source: Ensembl
Regulation of IRE1-mediated unfolded protein response Source: ParkinsonsUK-UCL
Regulation of JNK cascade Source: UniProtKB
Transcription-coupled nucleotide-excision repair Source: Reactome
Translation Source: ProtInc

Cellular Location

Cytosol; Nucleus; Perinuclear region; Synaptic vesicle. Nuclear localization is diminished in the presence of IFIT3.

View more

Anti-COPS5 antibodies

+ Filters

Loading...

Mouse Anti-COPS5 Recombinant Antibody (CBXC-1541) (CBMAB-C3528-CQ)

Compare

Target: COPS5

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXC-1541

Application*: WB

Mouse Anti-COPS5 Recombinant Antibody (CBCNC-064) (V2LY-1206-LY776)

Compare

Target: COPS5

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse

Clone: CBCNC-064

Application*: IP, WB, E

Rabbit Anti-COPS5 Recombinant Antibody (CBWJC-2959) (V2LY-1206-LY775)

Compare

Target: COPS5

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBWJC-2959

Application*: WB, IF, P

Mouse Anti-COPS5 Recombinant Antibody (CBXC-2053) (V2LY-1206-LY774)

Compare

Target: COPS5

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse, Rat

Clone: CBXC-2053

Application*: F, IF, IH, WB

Mouse Anti-COPS5 Recombinant Antibody (CBYY-C3193) (V2LY-1206-LY772)

Compare

Target: COPS5

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human, Mouse, Rat

Clone: CBYY-C3193

Application*: WB, IP, IF, E, P

Mouse Anti-COPS5 Recombinant Antibody (CBFYC-2099) (V2LY-1206-LY771)

Compare

Target: COPS5

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human, Mouse, Rat, Dog, Cattle, Pig

Clone: CBFYC-2099

Application*: WB, IP, IF, E

Rabbit Anti-COPS5 Recombinant Antibody (CBWJC-001) (V2LY-1206-LY770)

Compare

Target: COPS5

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBWJC-001

Application*: IH, IP, WB, IF

Mouse Anti-COPS5 Recombinant Antibody (0251) (V2LY-1206-LY769)

Compare

Target: COPS5

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse

Clone: 0251

Application*: IH, IP, WB

Mouse Anti-COPS5 Recombinant Antibody (2A10.8) (V2LY-1206-LY768)

Compare

Target: COPS5

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Common fruit fly, Human, Mouse, Rat

Clone: 2A10.8

Application*: WB, IF, P, IP

Mouse Anti-COPS5 Recombinant Antibody (0122) (V2LY-1206-LY767)

Compare

Target: COPS5

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Common fruit fly, Human, Mouse, Rat

Clone: 0122

Application*: WB, IF, P, IP

More Infomation

Submit A Review

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Submit A Review

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Hot products

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

online inquiry

Online Inquiry