COPS5

COPS5 (COP9 Signalosome Subunit 5) is a Protein Coding gene. Diseases associated with COPS5 include Xeroderma Pigmentosum, Complementation Group E. Among its related pathways are MIF Action Through Endocytic Pathway and Transcription-Coupled Nucleotide Excision Repair (TC-NER). Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and thiol-dependent ubiquitin-specific protease activity.

COP9 Signalosome Subunit 5

Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2.

Exosomal secretion Source: FlyBase
Negative regulation of apoptotic process Source: UniProtKB
Nucleotide-excision repair, DNA damage recognition Source: Reactome
Positive regulation of DNA-binding transcription factor activity Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Post-translational protein modification Source: Reactome
Protein deneddylation Source: UniProtKB
Protein deubiquitination Source: FlyBase
Regulation of cell cycle Source: Ensembl
Regulation of IRE1-mediated unfolded protein response Source: ParkinsonsUK-UCL
Regulation of JNK cascade Source: UniProtKB
Transcription-coupled nucleotide-excision repair Source: Reactome
Translation Source: ProtInc

Cytosol; Nucleus; Perinuclear region; Synaptic vesicle. Nuclear localization is diminished in the presence of IFIT3.