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Mouse Anti-CSF2RB Recombinant Antibody (CBXC-2127) (CBMAB-C4876-CQ)

This product is a mouse antibody that recognizes CSF2RB. The antibody CBXC-2127 can be used for immunoassay techniques such as: WB.
See all CSF2RB antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-2127
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human CSF2RB (NP_000386)
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Colony Stimulating Factor 2 Receptor Beta Common Subunit
Introduction
CSF2RB (Colony Stimulating Factor 2 Receptor Beta Common Subunit) is a Protein Coding gene. Diseases associated with CSF2RB include Surfactant Metabolism Dysfunction, Pulmonary, 5 and Hereditary Pulmonary Alveolar Proteinosis. Among its related pathways are RET signaling and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include receptor activity and interleukin-3 receptor activity.
Entrez Gene ID
1439
UniProt ID
P32927
Alternative Names
Colony Stimulating Factor 2 Receptor Beta Common Subunit; Colony Stimulating Factor 2 Receptor, Beta, Low-Affinity (Granulocyte-Macrophage); GM-CSF/IL-3/IL-5 Receptor Common Beta Subunit; Beta Common Cytokine Receptor; Beta-GM-CSF Receptor; CDw131; IL3RB; IL5RB; Interleukin 3 Receptor/Granulocyte-Macrophage Colony Stimulating Factor 3 Receptor, Beta (High Affinity);
Function
High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.
Biological Process
Cellular protein metabolic process Source: Reactome
Cellular response to interleukin-3 Source: GOC
Cytokine-mediated signaling pathway Source: Reactome
Interleukin-3-mediated signaling pathway Source: GOC
Interleukin-5-mediated signaling pathway Source: GOC
MAPK cascade Source: Reactome
Respiratory gaseous exchange by respiratory system Source: ProtInc
Response to lipopolysaccharide Source: Ensembl
Signal transduction Source: UniProtKB
Cellular Location
Membrane
Involvement in disease
Pulmonary surfactant metabolism dysfunction 5 (SMDP5):
A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.
Topology
Extracellular: 17-443
Helical: 444-460
Cytoplasmic: 461-897
PTM
May be phosphorylated by LYN.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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