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Mouse Anti-CTDSP2 Recombinant Antibody (CBWJC-3320) (CBMAB-C4526WJ)

This product is a Mouse antibody that recognizes CTDSP2. This antibody CBWJC-3320 can be used for immunoassay techniques such as: WB, IHC.
See all CTDSP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJC-3320
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Immunogen
Full length human recombinant protein of human CTDSP2(NP_005721) produced in E.coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS (PH 7.3), 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
Introduction
CTDSP2 (CTD Small Phosphatase 2) is a Protein Coding gene. Among its related pathways are Unfolded Protein Response (UPR) and Coregulation of Androgen receptor activity. Gene Ontology (GO) annotations related to this gene include phosphatase activity and CTD phosphatase activity. An important paralog of this gene is CTDSPL.
Entrez Gene ID
10106
UniProt ID
O14595
Alternative Names
CTD Small Phosphatase 2; Nuclear LIM Interactor-Interacting Factor 2; NLI-Interacting Factor 2; Small CTD Phosphatase 2; CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 2; Conserved Gene Amplified In Osteosarcoma; Small C-Terminal Domain Phosphatase 2; Protein OS-4;
Function
Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.
Biological Process
IRE1-mediated unfolded protein response Source: Reactome
Negative regulation of G1/S transition of mitotic cell cycle Source: Ensembl
Negative regulation of protein phosphorylation Source: Ensembl
Protein dephosphorylation Source: UniProtKB
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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