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Mouse Anti-CXCL1 Recombinant Antibody (CBFYC-2487) (CBMAB-C2560-FY)

This product is mouse antibody that recognizes CXCL1. The antibody CBFYC-2487 can be used for immunoassay techniques such as: Neut, WB.
See all CXCL1 antibodies

Summary

Host Animal
Mouse
Specificity
Rat
Clone
CBFYC-2487
Antibody Isotype
IgG1
Application
Neut, WB

Basic Information

Immunogen
Synthetic peptide correspoding to the part of the Nterminal of rat GRO/CINC1Ascites
Specificity
Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
C-X-C Motif Chemokine Ligand 1
Introduction
CXCL1 (C-X-C Motif Chemokine Ligand 1) is a Protein Coding gene. Diseases associated with CXCL1 include Kaposi Sarcoma and Melanoma. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include receptor binding and chemokine activity. An important paralog of this gene is CXCL2.
Entrez Gene ID
81503
UniProt ID
P14095
Alternative Names
Gro1; CINC-1
Function
Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity.
Biological Process
Actin cytoskeleton organization Source: ProtInc
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cellular response to lipopolysaccharide Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
Cytokine-mediated signaling pathway Source: Reactome
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: GO_Central
Intracellular signal transduction Source: ProtInc
Killing of cells of other organism Source: UniProtKB
Negative regulation of cell population proliferation Source: ProtInc
Nervous system development Source: ProtInc
Neutrophil chemotaxis Source: GO_Central
Neutrophil degranulation Source: Reactome
Signal transduction Source: ProtInc
Cellular Location
Secreted
PTM
N-terminal processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.

Jiang, Y., Xi, Y., Li, Y., Zuo, Z., Zeng, C., Fan, J., ... & Guo, Y. (2022). Ethanol promoting the upregulation of CXC Motif Chemokine Ligand 1（ CXCL1） and CXC Motif Chemokine Ligand 6（ CXCL6） in models of early alcoholic liver disease. Bioengineered, 13(3), 4688-4701.

Zeng, X., Dong, X., Ma, Y., & Yao, J. (2022). Chemokine (CXC motif) ligand 1 maintains the immune surveillance function of natural killer cells via the PDK2/mTOR signaling pathway. Cell Biology and Toxicology, 1-15.

Ciummo, S. L., D’Antonio, L., Sorrentino, C., Fieni, C., Lanuti, P., Stassi, G., ... & Di Carlo, E. (2021). The CXC motif chemokine ligand 1 sustains breast cancer stem cell self-renewal and promotes tumor progression and immune escape programs. Frontiers in Cell and Developmental Biology, 9, 1479.

Gong, Y. Z., Ma, H., Ruan, G. T., Zhu, L. C., Liao, X. W., Wang, S., ... & Gao, F. (2021). Diagnosis and prognostic value of CXC motif chemokine ligand 1 in colon adenocarcinoma based on The Cancer Genome Atlas and Guangxi cohort. Journal of Cancer, 12(18), 5506.

Wang, S., Wang, N., Huang, X., Yang, B., Zheng, Y., Zhang, J., ... & Wang, Z. (2020). Baohuoside i suppresses breast cancer metastasis by downregulating the tumor-associated macrophages/CXC motif chemokine ligand 1 pathway. Phytomedicine, 78, 153331.

Wang, S., Liu, X., Huang, R., Zheng, Y., Wang, N., Yang, B., ... & Wang, Z. (2019). XIAOPI formula inhibits breast Cancer stem cells via suppressing tumor-associated macrophages/CXC motif chemokine ligand 1 pathway. Frontiers in pharmacology, 1371.

Hatano, T., Yashiro, M., Fujikawa, H., & Motomura, H. (2018). CXC Motif Ligand 1 (CXCL1) from melanoma cells down-regulates the invasion of their metastatic melanoma cells. Oncotarget, 9(57), 31090.

Zhuo, C., Wu, X., Li, J., Hu, D., Jian, J., Chen, C., ... & Yang, C. (2018). Chemokine (CXC motif) ligand 1 is associated with tumor progression and poor prognosis in patients with colorectal cancer. Bioscience reports, 38(4).

Amin, M., Vakilian, A., Mahmoodi, M. H., Hassanshahi, G., Falahati-Pour, S. K., Dolatabadi, M. R., & Nadimi, A. E. (2017). Circulatory levels of CXC motif chemokine ligands 1, 9, and 10 are elevated in patients with ischemic stroke. The Eurasian journal of medicine, 49(2), 92.

Deftu, A. F., Filippi, A., Shibsaki, K., Gheorghe, R. O., Chiritoiu, M., & Ristoiu, V. (2017). Chemokine (CXC motif) ligand 1 (CXCL1) and chemokine (CXC motif) ligand 2 (CXCL2) modulate the activity of TRPV1+/IB4+ cultured rat dorsal root ganglia neurons upon short-term and acute application. Journal of Physiology and Pharmacology: an Official Journal of the Polish Physiological Society, 68(3), 385-395.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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