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CXCL1

CXCL1 (C-X-C Motif Chemokine Ligand 1) is a Protein Coding gene. Diseases associated with CXCL1 include Kaposi Sarcoma and Melanoma. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include receptor binding and chemokine activity. An important paralog of this gene is CXCL2.

Full Name

C-X-C Motif Chemokine Ligand 1

Function

Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity.

Biological Process

Actin cytoskeleton organization Source: ProtInc
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cellular response to lipopolysaccharide Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
Cytokine-mediated signaling pathway Source: Reactome
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: GO_Central
Intracellular signal transduction Source: ProtInc
Killing of cells of other organism Source: UniProtKB
Negative regulation of cell population proliferation Source: ProtInc
Nervous system development Source: ProtInc
Neutrophil chemotaxis Source: GO_Central
Neutrophil degranulation Source: Reactome
Signal transduction Source: ProtInc

Cellular Location

Secreted

PTM

N-terminal processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.

Anti-CXCL1 antibodies

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Rat Anti-CXCL1 Recombinant Antibody (C2890) (CBMAB-C2890-LY)

SDS

Target: CXCL1

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: C2890

Application*: N, WB, IH

Rat Anti-CXCL1 Recombinant Antibody (CBXC-1490) (V2LY-0125-LY614)

SDS

Target: CXCL1

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBXC-1490

Application*: N, WB, E

Rat Anti-CXCL1 Recombinant Antibody (CBYY-C0249) (V2LY-0125-LY613)

SDS

Target: CXCL1

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: CBYY-C0249

Application*: N, WB

Rabbit Anti-CXCL1 Recombinant Antibody (CBFYC-2490) (V2LY-0125-LY612)

SDS

Target: CXCL1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Rat

Clone: CBFYC-2490

Application*: N, WB

Mouse Anti-CXCL1 Recombinant Antibody (CBFYC-2488) (V2LY-0125-LY611)

SDS

Target: CXCL1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-2488

Application*: E

Mouse Anti-CXCL1 Recombinant Antibody (CBFYC-2487) (V2LY-0125-LY610)

SDS

Target: CXCL1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYC-2487

Application*: E

Mouse Anti-CXCL1 Recombinant Antibody (CBFYC-2486) (V2LY-0125-LY609)

SDS

Target: CXCL1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYC-2486

Application*: E

Mouse Anti-CXCL1 Recombinant Antibody (CBFYC-0507) (V2LY-0125-LY608)

SDS

Target: CXCL1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-0507

Application*: WB, IP, E

Mouse Anti-CXCL1 Recombinant Antibody (CBFYC-0426) (V2LY-0125-LY607)

SDS

Target: CXCL1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYC-0426

Application*: WB, IP, IF, E

Mouse Anti-CXCL1 Recombinant Antibody (CBFYM-1059) (V2LY-0125-LY606)

SDS

Target: CXCL1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat

Clone: CBFYM-1059

Application*: E, WB

Mouse Anti-CXCL1 Recombinant Antibody (CBLC-LY-018) (V2LY-0125-LY605)

SDS

Target: CXCL1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBLC-LY-018

Application*: E

Mouse Anti-CXCL1 Recombinant Antibody (7A11) (V2LY-0125-LY604)

SDS

Target: CXCL1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 7A11

Application*: E, WB

Mouse Anti-CXCL1 Recombinant Antibody (C2564) (V2LY-0125-LY602)

SDS

Target: CXCL1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat

Clone: C2564

Application*: E

Rabbit Anti-CXCL1 Recombinant Antibody (012) (V2LY-0125-LY601)

SDS

Target: CXCL1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 012

Application*: E

Mouse Anti-CXCL1 Recombinant Antibody (CBLG1-380) (V2LY-0125-LY599)

SDS

Target: CXCL1

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: CBLG1-380

Application*: N, WB

Mouse Anti-CXCL1 Recombinant Antibody (CBLG1-3132) (V2LY-0125-LY598)

SDS

Target: CXCL1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Rat

Clone: CBLG1-3132

Application*: WB, IH, IF, IP

Mouse Anti-CXCL1 Recombinant Antibody (CBFYH-0117) (V2LY-0125-LY597)

SDS

Target: CXCL1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Rat

Clone: CBFYH-0117

Application*: WB, IH, IF, IP

CXCL1 Matched Antibody Pair (321) (APMAB-321LY)

SDS

Target: CXCL1

Specificity: Human

CXCL1 Matched Antibody Pair (320) (APMAB-320LY)

SDS

Target: CXCL1

Specificity: Human

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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