CXCL1

CXCL1 (C-X-C Motif Chemokine Ligand 1) is a Protein Coding gene. Diseases associated with CXCL1 include Kaposi Sarcoma and Melanoma. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include receptor binding and chemokine activity. An important paralog of this gene is CXCL2.
Full Name
C-X-C Motif Chemokine Ligand 1
Function
Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity.
Biological Process
Actin cytoskeleton organization Source: ProtInc
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cellular response to lipopolysaccharide Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
Cytokine-mediated signaling pathway Source: Reactome
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: GO_Central
Intracellular signal transduction Source: ProtInc
Killing of cells of other organism Source: UniProtKB
Negative regulation of cell population proliferation Source: ProtInc
Nervous system development Source: ProtInc
Neutrophil chemotaxis Source: GO_Central
Neutrophil degranulation Source: Reactome
Signal transduction Source: ProtInc
Cellular Location
Secreted
PTM
N-terminal processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.
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Anti-CXCL1 antibodies

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Rat Anti-CXCL1 Recombinant Antibody (C2890) (CBMAB-C2890-LY)

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Target: CXCL1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: C2890
Application*: N, WB, IH
Functional Assay
Datasheet SDS

Rat Anti-CXCL1 Recombinant Antibody (CBXC-1490) (V2LY-0125-LY614)

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Target: CXCL1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXC-1490
Application*: N, WB, E
Functional Assay
Datasheet SDS

Rat Anti-CXCL1 Recombinant Antibody (CBYY-C0249) (V2LY-0125-LY613)

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Target: CXCL1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-C0249
Application*: N, WB
Functional Assay
Datasheet SDS

Rabbit Anti-CXCL1 Recombinant Antibody (CBFYC-2490) (V2LY-0125-LY612)

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Target: CXCL1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat
Clone: CBFYC-2490
Application*: N, WB
Functional Assay
Datasheet SDS

Mouse Anti-CXCL1 Recombinant Antibody (CBFYC-2488) (V2LY-0125-LY611)

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Target: CXCL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2488
Application*: E
Datasheet SDS

Mouse Anti-CXCL1 Recombinant Antibody (CBFYC-2487) (V2LY-0125-LY610)

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Target: CXCL1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYC-2487
Application*: E
Datasheet SDS

Mouse Anti-CXCL1 Recombinant Antibody (CBFYC-2486) (V2LY-0125-LY609)

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Target: CXCL1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-2486
Application*: E
Datasheet SDS

Mouse Anti-CXCL1 Recombinant Antibody (CBFYC-0507) (V2LY-0125-LY608)

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Target: CXCL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0507
Application*: WB, IP, E
Datasheet SDS

Mouse Anti-CXCL1 Recombinant Antibody (CBFYC-0426) (V2LY-0125-LY607)

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Target: CXCL1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-0426
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CXCL1 Recombinant Antibody (CBFYM-1059) (V2LY-0125-LY606)

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Target: CXCL1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: CBFYM-1059
Application*: E, WB
Datasheet SDS

Mouse Anti-CXCL1 Recombinant Antibody (CBLC-LY-018) (V2LY-0125-LY605)

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Target: CXCL1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBLC-LY-018
Application*: E
Datasheet SDS

Mouse Anti-CXCL1 Recombinant Antibody (7A11) (V2LY-0125-LY604)

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Target: CXCL1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 7A11
Application*: E, WB
Datasheet SDS

Mouse Anti-CXCL1 Recombinant Antibody (C2564) (V2LY-0125-LY602)

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Target: CXCL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: C2564
Application*: E
Datasheet SDS

Rabbit Anti-CXCL1 Recombinant Antibody (012) (V2LY-0125-LY601)

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Target: CXCL1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 012
Application*: E
Datasheet SDS

Mouse Anti-CXCL1 Recombinant Antibody (CBLG1-380) (V2LY-0125-LY599)

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Target: CXCL1
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBLG1-380
Application*: N, WB
Functional Assay
Datasheet SDS

Mouse Anti-CXCL1 Recombinant Antibody (CBLG1-3132) (V2LY-0125-LY598)

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Target: CXCL1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat
Clone: CBLG1-3132
Application*: WB, IH, IF, IP
Datasheet SDS

Mouse Anti-CXCL1 Recombinant Antibody (CBFYH-0117) (V2LY-0125-LY597)

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Target: CXCL1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Rat
Clone: CBFYH-0117
Application*: WB, IH, IF, IP
Datasheet SDS

CXCL1 Matched Antibody Pair (321) (APMAB-321LY)

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Target: CXCL1
Specificity: Human
Datasheet SDS

CXCL1 Matched Antibody Pair (320) (APMAB-320LY)

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Target: CXCL1
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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