Mouse Anti-CXCL1 Recombinant Antibody (CBFYC-0426) (V2LY-0125-LY607)

Name: Mouse Anti-CXCL1 Recombinant Antibody (CBFYC-0426)
SKU: V2LY-0125-LY607
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYC-0426

Application

WB, IP, IF, ELISA

Immunogen

Amino acids 87-106 at the C-terminus of human GROα.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:100-1:1,000
IP	1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Gelatin & PBS

Preservative

Sodium Azide

Concentration

0.2 mg/mL

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

C-X-C Motif Chemokine Ligand 1

Entrez Gene ID

2919

UniProt ID

P09341

Function

Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity.

Biological Process

Actin cytoskeleton organization Source: ProtInc
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cellular response to lipopolysaccharide Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
Cytokine-mediated signaling pathway Source: Reactome
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: GO_Central
Intracellular signal transduction Source: ProtInc
Killing of cells of other organism Source: UniProtKB
Negative regulation of cell population proliferation Source: ProtInc
Nervous system development Source: ProtInc
Neutrophil chemotaxis Source: GO_Central
Neutrophil degranulation Source: Reactome
Signal transduction Source: ProtInc

Cellular Location

Secreted

PTM

N-terminal processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.

Jiang, Y., Xi, Y., Li, Y., Zuo, Z., Zeng, C., Fan, J., ... & Guo, Y. (2022). Ethanol promoting the upregulation of CXC Motif Chemokine Ligand 1（ CXCL1） and CXC Motif Chemokine Ligand 6（ CXCL6） in models of early alcoholic liver disease. Bioengineered, 13(3), 4688-4701.

Zeng, X., Dong, X., Ma, Y., & Yao, J. (2022). Chemokine (CXC motif) ligand 1 maintains the immune surveillance function of natural killer cells via the PDK2/mTOR signaling pathway. Cell Biology and Toxicology, 1-15.

Ciummo, S. L., D’Antonio, L., Sorrentino, C., Fieni, C., Lanuti, P., Stassi, G., ... & Di Carlo, E. (2021). The CXC motif chemokine ligand 1 sustains breast cancer stem cell self-renewal and promotes tumor progression and immune escape programs. Frontiers in Cell and Developmental Biology, 9, 1479.

Gong, Y. Z., Ma, H., Ruan, G. T., Zhu, L. C., Liao, X. W., Wang, S., ... & Gao, F. (2021). Diagnosis and prognostic value of CXC motif chemokine ligand 1 in colon adenocarcinoma based on The Cancer Genome Atlas and Guangxi cohort. Journal of Cancer, 12(18), 5506.

Wang, S., Wang, N., Huang, X., Yang, B., Zheng, Y., Zhang, J., ... & Wang, Z. (2020). Baohuoside i suppresses breast cancer metastasis by downregulating the tumor-associated macrophages/CXC motif chemokine ligand 1 pathway. Phytomedicine, 78, 153331.

Wang, S., Liu, X., Huang, R., Zheng, Y., Wang, N., Yang, B., ... & Wang, Z. (2019). XIAOPI formula inhibits breast Cancer stem cells via suppressing tumor-associated macrophages/CXC motif chemokine ligand 1 pathway. Frontiers in pharmacology, 1371.

Hatano, T., Yashiro, M., Fujikawa, H., & Motomura, H. (2018). CXC Motif Ligand 1 (CXCL1) from melanoma cells down-regulates the invasion of their metastatic melanoma cells. Oncotarget, 9(57), 31090.

Zhuo, C., Wu, X., Li, J., Hu, D., Jian, J., Chen, C., ... & Yang, C. (2018). Chemokine (CXC motif) ligand 1 is associated with tumor progression and poor prognosis in patients with colorectal cancer. Bioscience reports, 38(4).

Amin, M., Vakilian, A., Mahmoodi, M. H., Hassanshahi, G., Falahati-Pour, S. K., Dolatabadi, M. R., & Nadimi, A. E. (2017). Circulatory levels of CXC motif chemokine ligands 1, 9, and 10 are elevated in patients with ischemic stroke. The Eurasian journal of medicine, 49(2), 92.

Deftu, A. F., Filippi, A., Shibsaki, K., Gheorghe, R. O., Chiritoiu, M., & Ristoiu, V. (2017). Chemokine (CXC motif) ligand 1 (CXCL1) and chemokine (CXC motif) ligand 2 (CXCL2) modulate the activity of TRPV1+/IB4+ cultured rat dorsal root ganglia neurons upon short-term and acute application. Journal of Physiology and Pharmacology: an Official Journal of the Polish Physiological Society, 68(3), 385-395.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

CXCL1 Matched Antibody Pair (320) (CAT#: APMAB-320LY)

CXCL1 Matched Antibody Pair (321) (CAT#: APMAB-321LY)

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Isotype control

For research use only. Not intended for any clinical use.

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