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Mouse Anti-DAP Recombinant Antibody (3C5) (CBMAB-D0201-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Death Associated Protein (DAP). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all DAP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3C5
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
DAP (AAH02726, 1 a.a. ~ 102 a.a) full-length recombinant protein with GST tag. The immunogen sequence: MSSPPEGKLE TKAGHPPAVK AGGMRIVQKH PHTGDTKEEK DKDDQEWESP SPPKPTVFIS GVIARGDKDF PPAAAQVAHQ KPHASMDKHP SPRTQHIQQP RK
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-102

Target

Full Name
Death Associated Protein
Introduction
DAP is a basic, proline-rich, 15-kD protein. The protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma.
Entrez Gene ID
1611
UniProt ID
P51397
Alternative Names
Death Associated Protein; DAP-1; Death-Associated Protein 1; DAP1;
Function
Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death.
Biological Process
Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Apoptotic process Source: MGI
Apoptotic signaling pathway Source: UniProtKB
Autophagy Source: UniProtKB-KW
Cellular response to amino acid starvation Source: UniProtKB
Negative regulation of autophagy Source: UniProtKB
Negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
PTM
Phosphorylated. Phosphorylation by MTOR inhibits the suppressive activity of DAP toward autophagy.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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