DAP

This gene encodes a basic, proline-rich, 15-kD protein. The protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

Death Associated Protein

Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death.

Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Apoptotic process Source: MGI
Apoptotic signaling pathway Source: UniProtKB
Autophagy Source: UniProtKB-KW
Cellular response to amino acid starvation Source: UniProtKB
Negative regulation of autophagy Source: UniProtKB
Negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB

Phosphorylated. Phosphorylation by MTOR inhibits the suppressive activity of DAP toward autophagy.