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Mouse Anti-DAP Recombinant Antibody (EG922) (V2LY-0125-LY1085)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
EG922
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA, IHC-P

Basic Information

Immunogen
Amino acids 11-45 near the N-terminus of human DAP-1.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:100-1:1,000
IP1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)
ELISA1:100-1:1,000
IF(ICC)1:50-1:500
IHC-P1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Gelatin & PBS
Preservative
Sodium Azide
Concentration
0.2 mg/mL
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Death Associated Protein
Entrez Gene ID
Human1611
Mouse223453
UniProt ID
HumanP51397
Function
Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death.
Biological Process
Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Apoptotic process Source: MGI
Apoptotic signaling pathway Source: UniProtKB
Autophagy Source: UniProtKB-KW
Cellular response to amino acid starvation Source: UniProtKB
Negative regulation of autophagy Source: UniProtKB
Negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
PTM
Phosphorylated. Phosphorylation by MTOR inhibits the suppressive activity of DAP toward autophagy.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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