Sign in or Register   Sign in or Register
  |  

Mouse Anti-DCN Recombinant Antibody (5E8E7) (CBMAB-D0373-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Decorin (DCN). The antibody can be used for immunoassay techniques, such as ELISA, WB, IHC-P, ICC, IF, FC.
See all DCN antibodies
Published Data
Fig.1 AF cells were positive to decorin (96.44 % expression).
...View More
Fig.2 In the confocal analysis (magnification 40x, scale bar = 20 µm) corresponding surface proteins to NP and AF were positive. AF cells were incubated with streptavidin-Alexa 488 (Green) and NP cells with streptavidin-Alexa 568 (Red) antibodies. Nuclei
...View More

Summary

Host Animal
Mouse
Specificity
Human
Clone
5E8E7
Antibody Isotype
IgG1
Application
ELISA, WB, IHC-P, ICC, IF, FC

Basic Information

Immunogen
Purified recombinant fragment of human DCN expressed in E. Coli
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Decorin
Introduction
DCN belongs to the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients.
Entrez Gene ID
1634
UniProt ID
P07585
Alternative Names
Decorin; Bone Proteoglycan II; SLRR1B; PG40; Dermatan Sulphate Proteoglycans II; Small Leucine-Rich Protein 1B; Proteoglycan Core Protein;
Function
May affect the rate of fibrils formation.
Biological Process
Aging Source: Ensembl
Animal organ morphogenesis Source: ProtInc
Chondroitin sulfate biosynthetic process Source: Reactome
Chondroitin sulfate catabolic process Source: Reactome
Dermatan sulfate biosynthetic process Source: Reactome
Extracellular matrix organization Source: Reactome
Kidney development Source: Ensembl
Negative regulation of angiogenesis Source: MGI
Negative regulation of endothelial cell migration Source: MGI
Negative regulation of vascular endothelial growth factor signaling pathway Source: MGI
Peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan Source: Ensembl
Placenta development Source: Ensembl
Positive regulation of autophagy Source: CACAO
Positive regulation of macroautophagy Source: MGI
Positive regulation of mitochondrial depolarization Source: MGI
Positive regulation of mitochondrial fission Source: MGI
Positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
Positive regulation of transcription by RNA polymerase II Source: MGI
Response to lipopolysaccharide Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Skeletal muscle tissue development Source: Ensembl
Wound healing Source: Ensembl
Cellular Location
Extracellular matrix
Involvement in disease
Corneal dystrophy, congenital stromal (CSCD):
A corneal dystrophy characterized by congenital corneal opacification consisting of a large number of flakes and spots throughout all layers of the stroma. It results in progressive, painless visual loss. Corneal erosions and photophobia are absent.
PTM
The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.

Balne, P. K., Gupta, S., Zhang, J., Bristow, D., Faubion, M., Heil, S. D., ... & Mohan, R. R. (2021). The functional role of decorin in corneal neovascularization in vivo. Experimental Eye Research, 207, 108610.

Shibata, S., Shibata, N., Ohtsuka, S., Yoshitomi, Y., Kiyokawa, E., Yonekura, H., ... & Kubo, E. (2021). Role of Decorin in Posterior Capsule Opacification and Eye Lens Development. Cells, 10(4), 863.

Han, B., Li, Q., Wang, C., Chandrasekaran, P., Zhou, Y., Qin, L., ... & Han, L. (2021). Differentiated activities of decorin and biglycan in the progression of post-traumatic osteoarthritis. Osteoarthritis and Cartilage, 29(8), 1181-1192.

Halari, C. D., Nandi, P., Jeyarajah, M. J., Renaud, S. J., & Lala, P. K. (2020). Decorin production by the human decidua: role in decidual cell maturation. Molecular Human Reproduction, 26(10), 784-796.

Reszegi, A., Horváth, Z., Fehér, H., Wichmann, B., Tátrai, P., Kovalszky, I., & Baghy, K. (2020). Protective role of decorin in primary hepatocellular carcinoma. Frontiers in oncology, 10, 645.

Daquinag, A. C., Gao, Z., Fussell, C., Sun, K., & Kolonin, M. G. (2020). Glycosaminoglycan modification of Decorin depends on MMP14 activity and regulates collagen assembly. Cells, 9(12), 2646.

Sainio, A. O., & Järveläinen, H. T. (2019). Decorin‐mediated oncosuppression–a potential future adjuvant therapy for human epithelial cancers. British Journal of Pharmacology, 176(1), 5-15.

Vu, T. T., Marquez, J., Le, L. T., Nguyen, A. T. T., Kim, H. K., & Han, J. (2018). The role of decorin in cardiovascular diseases: more than just a decoration. Free Radical Research, 52(11-12), 1210-1219.

Zhang, W., Ge, Y., Cheng, Q., Zhang, Q., Fang, L., & Zheng, J. (2018). Decorin is a pivotal effector in the extracellular matrix and tumour microenvironment. Oncotarget, 9(4), 5480.

Shen, Y., Russo, V., Zeglinski, M. R., Sellers, S. L., Wu, Z., Oram, C., ... & Granville, D. J. (2017). Recombinant decorin fusion protein attenuates murine abdominal aortic aneurysm formation and rupture. Scientific reports, 7(1), 1-9.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-DCN Recombinant Antibody (5E8E7)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare