Mouse Anti-DCN Recombinant Antibody (0172) (CBMAB-0172-CN)

Name: Mouse Anti-DCN Recombinant Antibody (0172)
SKU: CBMAB-0172-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

0172

Application

WB, IP, IF, ELISA

Immunogen

Amino acids 214-236 of mouse Decorin.

Host Species

Mouse

Specificity

Mouse

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:100-1:1,000
IP	1-2 μg per 100-500 μg of total protein (1 mL of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

< 0.1% sodium azide

Concentration

0.2 mg/ml

More Infomation

Target

Full Name

Decorin

Entrez Gene ID

13179

UniProt ID

P28654

Function

May affect the rate of fibrils formation.

Biological Process

Aging Source: Ensembl
Animal organ morphogenesis Source: ProtInc
Chondroitin sulfate biosynthetic process Source: Reactome
Chondroitin sulfate catabolic process Source: Reactome
Dermatan sulfate biosynthetic process Source: Reactome
Extracellular matrix organization Source: Reactome
Kidney development Source: Ensembl
Negative regulation of angiogenesis Source: MGI
Negative regulation of endothelial cell migration Source: MGI
Negative regulation of vascular endothelial growth factor signaling pathway Source: MGI
Peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan Source: Ensembl
Placenta development Source: Ensembl
Positive regulation of autophagy Source: CACAO
Positive regulation of macroautophagy Source: MGI
Positive regulation of mitochondrial depolarization Source: MGI
Positive regulation of mitochondrial fission Source: MGI
Positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
Positive regulation of transcription by RNA polymerase II Source: MGI
Response to lipopolysaccharide Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Skeletal muscle tissue development Source: Ensembl
Wound healing Source: Ensembl

Cellular Location

Extracellular matrix

Involvement in disease

Corneal dystrophy, congenital stromal (CSCD):
A corneal dystrophy characterized by congenital corneal opacification consisting of a large number of flakes and spots throughout all layers of the stroma. It results in progressive, painless visual loss. Corneal erosions and photophobia are absent.

PTM

The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.

Balne, P. K., Gupta, S., Zhang, J., Bristow, D., Faubion, M., Heil, S. D., ... & Mohan, R. R. (2021). The functional role of decorin in corneal neovascularization in vivo. Experimental Eye Research, 207, 108610.

Shibata, S., Shibata, N., Ohtsuka, S., Yoshitomi, Y., Kiyokawa, E., Yonekura, H., ... & Kubo, E. (2021). Role of Decorin in Posterior Capsule Opacification and Eye Lens Development. Cells, 10(4), 863.

Han, B., Li, Q., Wang, C., Chandrasekaran, P., Zhou, Y., Qin, L., ... & Han, L. (2021). Differentiated activities of decorin and biglycan in the progression of post-traumatic osteoarthritis. Osteoarthritis and Cartilage, 29(8), 1181-1192.

Halari, C. D., Nandi, P., Jeyarajah, M. J., Renaud, S. J., & Lala, P. K. (2020). Decorin production by the human decidua: role in decidual cell maturation. Molecular Human Reproduction, 26(10), 784-796.

Reszegi, A., Horváth, Z., Fehér, H., Wichmann, B., Tátrai, P., Kovalszky, I., & Baghy, K. (2020). Protective role of decorin in primary hepatocellular carcinoma. Frontiers in oncology, 10, 645.

Daquinag, A. C., Gao, Z., Fussell, C., Sun, K., & Kolonin, M. G. (2020). Glycosaminoglycan modification of Decorin depends on MMP14 activity and regulates collagen assembly. Cells, 9(12), 2646.

Sainio, A. O., & Järveläinen, H. T. (2019). Decorin‐mediated oncosuppression–a potential future adjuvant therapy for human epithelial cancers. British Journal of Pharmacology, 176(1), 5-15.

Vu, T. T., Marquez, J., Le, L. T., Nguyen, A. T. T., Kim, H. K., & Han, J. (2018). The role of decorin in cardiovascular diseases: more than just a decoration. Free Radical Research, 52(11-12), 1210-1219.

Zhang, W., Ge, Y., Cheng, Q., Zhang, Q., Fang, L., & Zheng, J. (2018). Decorin is a pivotal effector in the extracellular matrix and tumour microenvironment. Oncotarget, 9(4), 5480.

Shen, Y., Russo, V., Zeglinski, M. R., Sellers, S. L., Wu, Z., Oram, C., ... & Granville, D. J. (2017). Recombinant decorin fusion protein attenuates murine abdominal aortic aneurysm formation and rupture. Scientific reports, 7(1), 1-9.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

DCN Matched Antibody Pair (323) (CAT#: APMAB-323LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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