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Mouse Anti-DCN Recombinant Antibody (3B3) (CBMAB-0172-CN)

This product is a mouse antibody that recognizes DCN of bovine. The antibody 3B3 can be used for immunoassay techniques such as: ELISA.
See all DCN antibodies

Summary

Host Animal
Mouse
Specificity
Cattle, Human, Rabbit
Clone
3B3
Antibody Isotype
IgG1
Application
ELISA

Basic Information

Specificity
Cattle, Human, Rabbit
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Decorin
Introduction
This gene has 1 transcript (splice variant), 93 orthologues, 14 paralogues and is a member of 1 Ensembl protein family. The protein may affect the rate of fibrils formation.
Entrez Gene ID
Human1634
Cattle280760
Rabbit100009171
UniProt ID
HumanP07585
MouseP28654
CattleP21793
RabbitQ28888
Alternative Names
DCN
Function
May affect the rate of fibrils formation.
Biological Process
Aging Source: Ensembl
Animal organ morphogenesis Source: ProtInc
Chondroitin sulfate biosynthetic process Source: Reactome
Chondroitin sulfate catabolic process Source: Reactome
Dermatan sulfate biosynthetic process Source: Reactome
Extracellular matrix organization Source: Reactome
Kidney development Source: Ensembl
Negative regulation of angiogenesis Source: MGI
Negative regulation of endothelial cell migration Source: MGI
Negative regulation of vascular endothelial growth factor signaling pathway Source: MGI
Peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan Source: Ensembl
Placenta development Source: Ensembl
Positive regulation of autophagy Source: CACAO
Positive regulation of macroautophagy Source: MGI
Positive regulation of mitochondrial depolarization Source: MGI
Positive regulation of mitochondrial fission Source: MGI
Positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
Positive regulation of transcription by RNA polymerase II Source: MGI
Response to lipopolysaccharide Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Skeletal muscle tissue development Source: Ensembl
Wound healing Source: Ensembl
Cellular Location
Extracellular matrix
Involvement in disease
Corneal dystrophy, congenital stromal (CSCD):
A corneal dystrophy characterized by congenital corneal opacification consisting of a large number of flakes and spots throughout all layers of the stroma. It results in progressive, painless visual loss. Corneal erosions and photophobia are absent.
PTM
The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.

Balne, P. K., Gupta, S., Zhang, J., Bristow, D., Faubion, M., Heil, S. D., ... & Mohan, R. R. (2021). The functional role of decorin in corneal neovascularization in vivo. Experimental Eye Research, 207, 108610.

Shibata, S., Shibata, N., Ohtsuka, S., Yoshitomi, Y., Kiyokawa, E., Yonekura, H., ... & Kubo, E. (2021). Role of Decorin in Posterior Capsule Opacification and Eye Lens Development. Cells, 10(4), 863.

Han, B., Li, Q., Wang, C., Chandrasekaran, P., Zhou, Y., Qin, L., ... & Han, L. (2021). Differentiated activities of decorin and biglycan in the progression of post-traumatic osteoarthritis. Osteoarthritis and Cartilage, 29(8), 1181-1192.

Halari, C. D., Nandi, P., Jeyarajah, M. J., Renaud, S. J., & Lala, P. K. (2020). Decorin production by the human decidua: role in decidual cell maturation. Molecular Human Reproduction, 26(10), 784-796.

Reszegi, A., Horváth, Z., Fehér, H., Wichmann, B., Tátrai, P., Kovalszky, I., & Baghy, K. (2020). Protective role of decorin in primary hepatocellular carcinoma. Frontiers in oncology, 10, 645.

Daquinag, A. C., Gao, Z., Fussell, C., Sun, K., & Kolonin, M. G. (2020). Glycosaminoglycan modification of Decorin depends on MMP14 activity and regulates collagen assembly. Cells, 9(12), 2646.

Sainio, A. O., & Järveläinen, H. T. (2019). Decorin‐mediated oncosuppression–a potential future adjuvant therapy for human epithelial cancers. British Journal of Pharmacology, 176(1), 5-15.

Vu, T. T., Marquez, J., Le, L. T., Nguyen, A. T. T., Kim, H. K., & Han, J. (2018). The role of decorin in cardiovascular diseases: more than just a decoration. Free Radical Research, 52(11-12), 1210-1219.

Zhang, W., Ge, Y., Cheng, Q., Zhang, Q., Fang, L., & Zheng, J. (2018). Decorin is a pivotal effector in the extracellular matrix and tumour microenvironment. Oncotarget, 9(4), 5480.

Shen, Y., Russo, V., Zeglinski, M. R., Sellers, S. L., Wu, Z., Oram, C., ... & Granville, D. J. (2017). Recombinant decorin fusion protein attenuates murine abdominal aortic aneurysm formation and rupture. Scientific reports, 7(1), 1-9.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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