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Mouse Anti-DEFA5 Recombinant Antibody (CBWJN-0451) (CBMAB-N0709-WJ)

This product is a Mouse antibody that recognizes DEFA5. The antibody CBWJN-0451 can be used for immunoassay techniques such as: ELISA, FC, IHC, WB.
See all DEFA5 antibodies

Summary

Host Animal
Mouse
Specificity
Rabbit
Clone
CBWJN-0451
Antibody Isotype
IgG2a
Application
ELISA, FC, IHC, WB

Basic Information

Specificity
Rabbit
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% BSA
Preservative
0.02% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Defensin Alpha 5
Introduction
Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum. [provided by RefSeq, Oct 2014]
Entrez Gene ID
1670
UniProt ID
Q01523
Alternative Names
Defensin Alpha 5; Defensin, Alpha 5, Paneth Cell-Specific; HD5(20-94); DEF5; Defensin, Alpha 5, Preproprotein; Defensin, Alpha 5; Defensin-5; HD-5;

Luan, J., Ren, Y., Gao, S., & Zhang, L. (2022). High level of defensin alpha 5 in intestine may explain the low incidence of diarrhoea in COVID-19 patients. European Journal of Gastroenterology & Hepatology.

Qiao, Q., Bai, R., Song, W., Gao, H., Zhang, M., Lu, J., ... & Zhao, P. (2021). Human α-defensin 5 suppressed colon cancer growth by targeting PI3K pathway. Experimental Cell Research, 407(2), 112809.

Rana, T., Korolkova, O. Y., Rachakonda, G., Williams, A. D., Hawkins, A. T., James, S. D., ... & M’Koma, A. E. (2021). Linking bacterial enterotoxins and alpha defensin 5 expansion in the Crohn’s colitis: A new insight into the etiopathogenetic and differentiation triggers driving colonic inflammatory bowel disease. Plos one, 16(3), e0246393.

Wu, Z., Ding, Z., Cheng, B., & Cui, Z. (2021). The inhibitory effect of human DEFA5 in growth of gastric cancer by targeting BMI1. Cancer science, 112(3), 1075-1083.

Larsen, I. S., Fritzen, A. M., Carl, C. S., Agerholm, M., Damgaard, M. T. F., Holm, J. B., ... & Jensen, B. A. H. (2019). Human Paneth cell α-defensin-5 treatment reverses dyslipidemia and improves glucoregulatory capacity in diet-induced obese mice. American Journal of Physiology-Endocrinology and Metabolism, 317(1), E42-E52.

Rashidi, A., Shanley, R., Holtan, S. G., MacMillan, M. L., Yohe, S., Thyagarajan, B., ... & Weisdorf, D. J. (2018). Single Nucleotide Polymorphisms of Paneth Cell Antimicrobial Alpha Defensin-5 (DEFA5) are Associated with Acute Graft-Versus-Host Disease: Results From Analysis of BMT-CTN0201 Samples. Biology of Blood and Marrow Transplantation, 24(3), S174-S175.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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