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Rabbit Anti-DGKK Recombinant Antibody (EG955) (CBMAB-EN1134-LY)

The product is antibody recognizes DGKK. The antibody EG955 immunoassay techniques such as: IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:5000.
See all DGKK antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG955
Antibody Isotype
IgG
Application
IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:5000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from C-terminal of human DGKK.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Diacylglycerol Kinase Kappa
Introduction
The protein encoded by this gene is an enzyme that phosphorylates diacylglycerol, converting it to phosphatidic acid. The encoded protein is a membrane protein and is inhibited by hydrogen peroxide. Variations in this gene have been associated with hypospadias. [provided by RefSeq, Mar 2011]
Entrez Gene ID
139189
UniProt ID
Q5KSL6
Alternative Names
Diacylglycerol Kinase Kappa; 142 KDa Diacylglycerol Kinase; Diglyceride Kinase Kappa; DAG Kinase Kappa; EC 2.7.1.107; DGK-Kappa;
Function
Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:16210324, PubMed:23949095).

Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable).
Biological Process
Diacylglycerol metabolic process Source: HGNC-UCL
Intracellular signal transduction Source: HGNC-UCL
Lipid phosphorylation Source: GO_Central
Platelet activation Source: Reactome
Protein kinase C-activating G protein-coupled receptor signaling pathway Source: InterPro
Response to oxidative stress Source: HGNC-UCL
Cellular Location
Cell membrane
PTM
Phosphorylated at Tyr-78 by some member of the SRC family in response to H2O2.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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