DGKK

The protein encoded by this gene is an enzyme that phosphorylates diacylglycerol, converting it to phosphatidic acid. The encoded protein is a membrane protein and is inhibited by hydrogen peroxide. Variations in this gene have been associated with hypospadias. [provided by RefSeq, Mar 2011]

Full Name

Diacylglycerol Kinase Kappa

Function

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:16210324, PubMed:23949095).

Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable).

Biological Process

Diacylglycerol metabolic process Source: HGNC-UCL
Intracellular signal transduction Source: HGNC-UCL
Lipid phosphorylation Source: GO_Central
Platelet activation Source: Reactome
Protein kinase C-activating G protein-coupled receptor signaling pathway Source: InterPro
Response to oxidative stress Source: HGNC-UCL

Cellular Location

Cell membrane

PTM

Phosphorylated at Tyr-78 by some member of the SRC family in response to H2O2.

Anti-DGKK antibodies

Mouse Anti-DGKK Recombinant Antibody (4G12) (CBMAB-D0793-YC)

Datasheet

SDS

Target: DGKK

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 4G12

Application*: WB, IP, E

Rabbit Anti-DGKK Recombinant Antibody (EG955) (CBMAB-EN1134-LY)

Datasheet

SDS

Target: DGKK

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: EG955

Application*: IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:5000

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)