Human Recombinant DGKK, Active protein, His Tag (V2LY-0526-LY3573)

Name: Human Recombinant DGKK, Active protein, His Tag
SKU: V2LY-0526-LY3573
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant DGKK, Active protein, His Tag consist of Amino Acid: Full Length and predicts a molecular mass of 145 kDa.

Molecule Mass

145 kDa

Sequence

Amino Acid: Full Length

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

Diacylglycerol Kinase Kappa

Function

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:16210324, PubMed:23949095).

Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable).

Biological Process

Diacylglycerol metabolic process Source: HGNC-UCL
Intracellular signal transduction Source: HGNC-UCL
Lipid phosphorylation Source: GO_Central
Platelet activation Source: Reactome
Protein kinase C-activating G protein-coupled receptor signaling pathway Source: InterPro
Response to oxidative stress Source: HGNC-UCL

Cellular Location

Cell membrane

PTM

Phosphorylated at Tyr-78 by some member of the SRC family in response to H2O2.

Habbas, K., Cakil, O., Zámbó, B., Tabet, R., Riet, F., Dembele, D., ... & Moine, H. (2022). AAV‐delivered diacylglycerol kinase DGKk achieves long‐term rescue of fragile X syndrome mouse model. EMBO Molecular Medicine, e14649.

Hozyasz, K. K., Mostowska, A., Kowal, A., Mydlak, D., & Tsibulski, A. (2018). Further evidence of the association of the diacylglycerol kinase kappa (DGKK) gene with hypospadias. Urology Journal, 15(5), 272-276.

Xie, H., Lin, X. L., Zhang, S., Yu, L., Li, X. X., Huang, Y. C., ... & Chen, F. (2018). Association between diacylglycerol kinase kappa variants and hypospadias susceptibility in a Han Chinese population. Asian Journal of Andrology, 20(1), 85.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant DGKK, Active protein, GST Tag (CAT#: V2LY-0526-LY3572)

Related Products

Human Recombinant DGKK, Active protein, GST Tag (CAT#: V2LY-0526-LY3572)

Mouse Anti-DGKK Recombinant Antibody (4G12) (CAT#: CBMAB-D0793-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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