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Rabbit Anti-DLG2 Recombinant Antibody (BA0363) (CBMAB-0259CQ)

This product is a rabbit antibody that recognizes DLG2. The antibody BA0363 can be used for immunoassay techniques such as: FC, IP, WB.
See all DLG2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
BA0363
Antibody Isotype
IgG
Application
FC, IP, WB

Basic Information

Immunogen
Synthetic peptide from residues in Human PSD93
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Discs Large MAGUK Scaffold Protein 2
Introduction
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. By analysis of radiation hybrid mapping panels and by inclusion within mapped clones. The DLG2 gene to 11q21. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described, but their full-length nature is not known.
Entrez Gene ID
Human1740
Mouse23859
Rat64053
UniProt ID
HumanQ15700
MouseQ91XM9
RatQ63622
Alternative Names
Discs, Large Homolog 2 (Drosophila); Channel-Associated Protein Of Synapse-110; Postsynaptic Density Protein PSD-93; Chapsyn-110; Discs, Large Homolog 2, Chapsyn-110 (Drosophila); Channel-Associated Protein Of Synapses, 110kDa; Protein Phosphatase 1, Regulatory Subunit 58; Discs, Large Homolog 2, Chapsyn-110; Protein Phosphatase 1; Regulatory Subunit 58; Discs Large 2; PPP1R58; PSD-93; PSD93
Function
Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity).
Biological Process
Anterograde axonal protein transport Source: ARUK-UCL
Cell-cell adhesion Source: GO_Central
Cellular response to potassium ion Source: ARUK-UCL
Chemical synaptic transmission Source: GO_Central
Establishment or maintenance of epithelial cell apical/basal polarity Source: GO_Central
Receptor clustering Source: GO_Central
Receptor localization to synapse Source: GO_Central
Retrograde axonal protein transport Source: ARUK-UCL
Cellular Location
Cell membrane; Postsynaptic density; Synapse; Membrane; Axon; Perikaryon. Concentrated in soma and postsynaptic density of a subset of neurons.
PTM
Palmitoylation of isoform 1 is not required for targeting to postsynaptic density.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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