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Mouse Anti-DLG2 Recombinant Antibody (13F7) (CBMAB-0485-CN)

This product is a mouse antibody that recognizes DLG2 of human. The antibody 13F7 can be used for immunoassay techniques such as: ELISA, MA.
See all DLG2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
13F7
Antibody Isotype
IgG
Application
ELISA, MA

Basic Information

Immunogen
Recombinant protein of DLG2 (aa. 143-277)
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Discs Large MAGUK Scaffold Protein 2
Introduction
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity).
Entrez Gene ID
1740
UniProt ID
Q15700
Alternative Names
Discs, Large Homolog 2 (Drosophila); Channel-Associated Protein Of Synapse-110; Postsynaptic Density Protein PSD-93; Chapsyn-110; Discs, Large Homolog 2, Chapsyn-110 (Drosophila); Channel-Associated Protein Of Synapses, 110kDa; Protein Phosphatase 1, Regulatory Subunit 58; Discs, Large Homolog 2, Chapsyn-110; Protein Phosphatase 1; Regulatory Subunit 58; Discs Large 2; PPP1R58; PSD-93; PSD93
Function
Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity).
Biological Process
Anterograde axonal protein transport Source: ARUK-UCL
Cell-cell adhesion Source: GO_Central
Cellular response to potassium ion Source: ARUK-UCL
Chemical synaptic transmission Source: GO_Central
Establishment or maintenance of epithelial cell apical/basal polarity Source: GO_Central
Receptor clustering Source: GO_Central
Receptor localization to synapse Source: GO_Central
Retrograde axonal protein transport Source: ARUK-UCL
Cellular Location
Cell membrane; Postsynaptic density; Synapse; Membrane; Axon; Perikaryon. Concentrated in soma and postsynaptic density of a subset of neurons.
PTM
Palmitoylation of isoform 1 is not required for targeting to postsynaptic density.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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