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DLG2

This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described, but their full-length nature is not known. [provided by RefSeq, Dec 2008]
Full Name
Discs Large MAGUK Scaffold Protein 2
Function
Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity).
Biological Process
Anterograde axonal protein transport Source: ARUK-UCL
Cell-cell adhesion Source: GO_Central
Cellular response to potassium ion Source: ARUK-UCL
Chemical synaptic transmission Source: GO_Central
Establishment or maintenance of epithelial cell apical/basal polarity Source: GO_Central
Receptor clustering Source: GO_Central
Receptor localization to synapse Source: GO_Central
Retrograde axonal protein transport Source: ARUK-UCL
Cellular Location
Cell membrane; Postsynaptic density; Synapse; Membrane; Axon; Perikaryon. Concentrated in soma and postsynaptic density of a subset of neurons.
PTM
Palmitoylation of isoform 1 is not required for targeting to postsynaptic density.
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Anti-DLG2 antibodies

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Mouse Anti-DLG2 Recombinant Antibody (13F7) (CBMAB-0485-CN)

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Target: DLG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 13F7
Application*: IF, IH, IP, WB
Datasheet SDS

Rabbit Anti-DLG2 Recombinant Antibody (CP2098) (V2LY-0425-LY443)

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Target: DLG2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CP2098
Application*: WB, IF
Datasheet SDS

Mouse Anti-DLG2 Recombinant Antibody (CBFYC-2587) (V2LY-0425-LY442)

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Target: DLG2
Host: Mouse
Antibody Isotype: IgG1, λ
Specificity: Human, Mouse, Rat
Clone: CBFYC-2587
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-DLG2 Recombinant Antibody (CBYCD-298) (V2LY-0425-LY441)

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Target: DLG2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBYCD-298
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-DLG2 Recombinant Antibody (CBLNC-154) (V2LY-0425-LY440)

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Target: DLG2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Rat, Human, Mouse
Clone: CBLNC-154
Application*: IH, WB
Datasheet SDS

Rabbit Anti-DLG2 Recombinant Antibody (7H7L3) (V2LY-0425-LY439)

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Target: DLG2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 7H7L3
Application*: WB, F, IP
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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