Mouse Anti-DLG2 Recombinant Antibody (CBFYC-2587) (V2LY-0425-LY442)

Name: Mouse Anti-DLG2 Recombinant Antibody (CBFYC-2587)
SKU: V2LY-0425-LY442
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Mouse, Rat

Clone

CBFYC-2587

Antibody Isotype

IgG1, λ

Application

WB, IP, IF, ELISA

Basic Information

Immunogen

Amino acids 1-300 mapping at the N-terminus of human PSD-93.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1, λ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Gelatin & PBS

Preservative

Sodium Azide

Concentration

0.2 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Discs Large MAGUK Scaffold Protein 2

Entrez Gene ID

Human	1740
Mouse	23859
Rat	64053

UniProt ID

Human	Q15700
Mouse	Q91XM9
Rat	Q63622

Function

Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity).

Biological Process

Anterograde axonal protein transport Source: ARUK-UCL
Cell-cell adhesion Source: GO_Central
Cellular response to potassium ion Source: ARUK-UCL
Chemical synaptic transmission Source: GO_Central
Establishment or maintenance of epithelial cell apical/basal polarity Source: GO_Central
Receptor clustering Source: GO_Central
Receptor localization to synapse Source: GO_Central
Retrograde axonal protein transport Source: ARUK-UCL

Cellular Location

Cell membrane; Postsynaptic density; Synapse; Membrane; Axon; Perikaryon. Concentrated in soma and postsynaptic density of a subset of neurons.

PTM

Palmitoylation of isoform 1 is not required for targeting to postsynaptic density.

More Infomation

References

Pass, R., Haan, N., Humby, T., Wilkinson, L. S., Hall, J., & Thomas, K. L. (2022). Selective behavioural impairments in mice heterozygous for the cross disorder psychiatric risk gene DLG2. Genes, Brain and Behavior, 21(4), e12799.

Yoo, T., Kim, S. G., Yang, S. H., Kim, H., Kim, E., & Kim, S. Y. (2020). A DLG2 deficiency in mice leads to reduced sociability and increased repetitive behavior accompanied by aberrant synaptic transmission in the dorsal striatum. Molecular Autism, 11(1), 1-14.

Shao, Y. W., Wood, G. A., Lu, J., Tang, Q. L., Liu, J., Molyneux, S., ... & Khokha, R. (2019). Cross-species genomics identifies DLG2 as a tumor suppressor in osteosarcoma. Oncogene, 38(2), 291-298.

Wu, H. C., Chen, C. M., Chen, Y. C., Fung, H. C., Chang, K. H., & Wu, Y. R. (2018). DLG2, but not TMEM229B, GPNMB, and ITGA8 polymorphism, is associated with Parkinson's disease in a Taiwanese population. Neurobiology of Aging, 64, 158-e1.

Ali, S., Hoven, A., Dress, R. J., Schaal, H., Alferink, J., & Scheu, S. (2018). Identification of a novel Dlg2 isoform differentially expressed in IFNβ-producing plasmacytoid dendritic cells. BMC genomics, 19(1), 1-12.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Alternative Versions

Mouse Anti-DLG2 (AA 1-852) Recombinant Antibody (CBFYC-2587)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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