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Mouse Anti-DLX3 Antibody (2C4) (CBMAB-0292-YC)

Provided herein are mouse monoclonal antibodies against Human DLX3. The antibody clone 2C4 can be used for immunoassay techniques, such as WB and MA.
See all DLX3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2C4
Antibody Isotype
IgG1
Application
WB, MA

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Distal-Less Homeobox 3
Introduction
DLX3 (distal-less homeobox 3) is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 17. Mutations in this gene have been associated with the autosomal dominant conditions trichodentoosseous syndrome and amelogenesis imperfecta with taurodontism. Trichodentoosseous syndrome (TDO), an autosomal dominant condition, has been correlated with DLX3 gene mutation.
Entrez Gene ID
1747
UniProt ID
O60479
Alternative Names
Distal-Less Homeobox 3; Distal-Less Homeo Box 3; TDO 3; AI4
Function
Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.
Biological Process
Blood vessel development Source: Ensembl
Cell differentiation Source: GO_Central
Epithelial cell differentiation Source: GO_Central
Odontoblast differentiation Source: Ensembl
Odontogenesis of dentin-containing tooth Source: Ensembl
Placenta development Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Trichodentoosseous syndrome (TDO):
An autosomal dominant disease characterized by curly kinky hair at birth, enamel hypoplasia, taurodontism, thickening of cortical bones and variable expression of craniofacial morphology.
Amelogenesis imperfecta 4 (AI4):
An autosomal dominant defect of enamel formation associated with enlarged pulp chambers. Enamel is thin, teeth are small and widely spaced.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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