Mouse Anti-DLX3 Recombinant Antibody (3C3) (CBMAB-A2274-LY)

Name: Mouse Anti-DLX3 Recombinant Antibody (3C3)
SKU: CBMAB-A2274-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3C3

Application

WB, ELISA

Immunogen

DLX3 full-length recombinant protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Distal-Less Homeobox 3

Introduction

Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. Trichodentoosseous syndrome (TDO), an autosomal dominant condition, has been correlated with DLX3 gene mutation. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 17. Mutations in this gene have been associated with the autosomal dominant conditions trichodentoosseous syndrome and amelogenesis imperfecta with taurodontism. [provided by RefSeq]

Entrez Gene ID

1747

UniProt ID

O60479

Alternative Names

AI4; TDO

Function

Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.

Biological Process

Blood vessel development Source: Ensembl
Cell differentiation Source: GO_Central
Epithelial cell differentiation Source: GO_Central
Odontoblast differentiation Source: Ensembl
Odontogenesis of dentin-containing tooth Source: Ensembl
Placenta development Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus

Involvement in disease

Trichodentoosseous syndrome (TDO):
An autosomal dominant disease characterized by curly kinky hair at birth, enamel hypoplasia, taurodontism, thickening of cortical bones and variable expression of craniofacial morphology.
Amelogenesis imperfecta 4 (AI4):
An autosomal dominant defect of enamel formation associated with enlarged pulp chambers. Enamel is thin, teeth are small and widely spaced.

Hou, F., Jin, H., Cao, L., Jiao, X., Wang, B., Liu, H., & Cui, B. (2022). The Imbalance Expression of DLX3 May Perform Critical Function in the Occurrence and Progression of Preeclampsia. Computational and Mathematical Methods in Medicine, 2022.

Li, J., Lin, Q., Lin, Y., Lai, R., & Zhang, W. (2021). Effects of DLX3 on the osteogenic differentiation of induced pluripotent stem cell‑derived mesenchymal stem cells. Molecular Medicine Reports, 23(4), 1-1.

Qadir, A. S., Lee, J., Lee, Y. S., Woo, K. M., Ryoo, H. M., & Baek, J. H. (2019). Distal‐less homeobox 3, a negative regulator of myogenesis, is downregulated by microRNA‐133. Journal of Cellular Biochemistry, 120(2), 2226-2235.

Sun, S., Yu, M., Fan, Z., Yeh, I. T., Feng, H., Liu, H., & Han, D. (2019). DLX3 regulates osteogenic differentiation of bone marrow mesenchymal stem cells via Wnt/β-catenin pathway mediated histone methylation of DKK4. Biochemical and biophysical research communications, 516(1), 171-176.

Chiu, Y. H., Yang, M. R., Wang, L. J., Chen, M. H., Chang, G. D., & Chen, H. (2018). New insights into the regulation of placental growth factor gene expression by the transcription factors GCM1 and DLX3 in human placenta. Journal of Biological Chemistry, 293(25), 9801-9811.

Zeng, L., Zhao, N., Li, F., Han, D., Liu, Y., Liu, H., ... & Feng, H. (2018). miR-675 promotes odontogenic differentiation of human dental pulp cells by epigenetic regulation of DLX3. Experimental Cell Research, 367(1), 104-111.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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