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DLX3

Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. Trichodentoosseous syndrome (TDO), an autosomal dominant condition, has been correlated with DLX3 gene mutation. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 17. Mutations in this gene have been associated with the autosomal dominant conditions trichodentoosseous syndrome and amelogenesis imperfecta with taurodontism. [provided by RefSeq, Jul 2008]
Full Name
Distal-Less Homeobox 3
Function
Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.
Biological Process
Blood vessel development Source: Ensembl
Cell differentiation Source: GO_Central
Epithelial cell differentiation Source: GO_Central
Odontoblast differentiation Source: Ensembl
Odontogenesis of dentin-containing tooth Source: Ensembl
Placenta development Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Trichodentoosseous syndrome (TDO):
An autosomal dominant disease characterized by curly kinky hair at birth, enamel hypoplasia, taurodontism, thickening of cortical bones and variable expression of craniofacial morphology.
Amelogenesis imperfecta 4 (AI4):
An autosomal dominant defect of enamel formation associated with enlarged pulp chambers. Enamel is thin, teeth are small and widely spaced.
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Anti-DLX3 antibodies

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Mouse Anti-DLX3 Recombinant Antibody (D1135) (V2LY-0425-LY521)

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Target: DLX3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: D1135
Application*: E, WB, IP
Datasheet SDS

Mouse Anti-DLX3 Recombinant Antibody (4F8) (V2LY-0425-LY520)

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Target: DLX3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4F8
Application*: E, WB
Datasheet SDS

Mouse Anti-DLX3 Recombinant Antibody (3B8) (V2LY-0425-LY518)

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Target: DLX3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3B8
Application*: E, WB
Datasheet SDS

Mouse Anti-DLX3 Monoclonal Antibody (2C4) (V2LY-0425-LY516)

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Target: DLX3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C4
Application*: WB
Datasheet SDS

Rabbit Anti-DLX3 Recombinant Antibody (EG970) (CBMAB-EN1152-LY)

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Target: DLX3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG970
Application*: WB
Datasheet SDS

Mouse Anti-DLX3 Recombinant Antibody (3C3) (CBMAB-A2274-LY)

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Target: DLX3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3C3
Application*: WB, E
Datasheet SDS

Mouse Anti-DLX3 Recombinant Antibody (3F7) (CBMAB-D1133-YC)

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Target: DLX3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3F7
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-DLX3 Recombinant Antibody (D1130) (CBMAB-D1130-YC)

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Target: DLX3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: D1130
Application*: WB, IP, IF, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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